Screening and validation of serum protein biomarkers for early postmenopausal osteoporosis diagnosis

  • Authors:
    • Long Wang
    • Ya‑Qian Hu
    • Zhuo‑Jie Zhao
    • Hong‑Yang Zhang
    • Bo Gao
    • Wei‑Guang Lu
    • Xiao‑Long Xu
    • Xi‑Sheng Lin
    • Jin‑Peng Wang
    • Qiang Jie
    • Zhuo‑Jing Luo
    • Liu Yang
  • View Affiliations

  • Published online on: September 26, 2017     https://doi.org/10.3892/mmr.2017.7620
  • Pages:8427-8433
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Abstract

Postmenopausal osteoporosis is one of the most prominent worldwide public health problems and the morbidity is increasing with the aging population. It has been demonstrated that early diagnosis and intervention delay the disease progression and improve the outcome. Therefore, searching for biomarkers that are able to identify postmenopausal women at high risk for developing osteoporosis is an effective way to improve the quality of life of patients, and alleviate social and economic burdens. In the present study, a protein array was used to identify potential biomarkers. The bone mineral densities of 10 rats were dynamically measured in an ovariectomized model by micro‑computed tomography assessment, and the early stage of osteoporosis was defined. Through the protein array‑based screening, the expression levels of six serum protein biomarkers in ovariectomized rats were observed to alter at the initiation stage of the postmenopausal osteoporosis. Fractalkine, tissue inhibitor of metalloproteinases‑1 and monocyte chemotactic protein‑1 were finally demonstrated to be increased in the serum of eight enrolled postmenopausal osteoporosis patients using ELISA assay and were correlated with the severity of progressive bone loss. These biomarkers may be explored as potential early biomarkers to readily evaluate and diagnose postmenopausal osteoporosis in the clinic.

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December 2017
Volume 16 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

2016 Impact Factor: 1.692
Ranked #19/128 Medicine Research and Experimental
(total number of cites)

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APA
Wang, L., Hu, Y., Zhao, Z., Zhang, H., Gao, B., Lu, W. ... Yang, L. (2017). Screening and validation of serum protein biomarkers for early postmenopausal osteoporosis diagnosis. Molecular Medicine Reports, 16, 8427-8433. https://doi.org/10.3892/mmr.2017.7620
MLA
Wang, L., Hu, Y., Zhao, Z., Zhang, H., Gao, B., Lu, W., Xu, X., Lin, X., Wang, J., Jie, Q., Luo, Z., Yang, L."Screening and validation of serum protein biomarkers for early postmenopausal osteoporosis diagnosis". Molecular Medicine Reports 16.6 (2017): 8427-8433.
Chicago
Wang, L., Hu, Y., Zhao, Z., Zhang, H., Gao, B., Lu, W., Xu, X., Lin, X., Wang, J., Jie, Q., Luo, Z., Yang, L."Screening and validation of serum protein biomarkers for early postmenopausal osteoporosis diagnosis". Molecular Medicine Reports 16, no. 6 (2017): 8427-8433. https://doi.org/10.3892/mmr.2017.7620