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High‑cholesterol diet results in elevated amyloid‑β and oxysterols in rats

  • Authors:
    • Quanri Liu
    • Yu An
    • Weiwei Ma
    • Lingli Feng
    • Chao Wang
    • Yanhui Lu
    • Rong Xiao

  • View Affiliations

  • Published online on: November 7, 2017     https://doi.org/10.3892/mmr.2017.8003
  • Pages: 1235-1240
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

The aim of the present study was to investigate the effects of diet cholesterol on oxysterol levels and amyloid‑β (Aβ) production in the peripheral blood and the brains of Sprague‑Dawley (SD) rats. SD rats were randomly divided into five groups and fed 0.015, 0.05, 0.2, 0.5 and 1.6% cholesterol‑containing diets for 8 weeks. The effect of the different diets on the levels of cholesterol, oxysterols [including 27‑hydroxycholesterol (OHC), 24S‑OHC, 7α‑OHC and 7β‑OHC], and the Aβ1‑40 and Aβ1‑42 peptides were examined in the plasma and the brain of the rats. The results demonstrated that diet cholesterol increased the levels of plasma cholesterol in a dose‑dependent manner. The plasma levels of 27‑OHC, 7α‑OHC and 7β‑OHC significantly increased in the 0.5 and 1.6% cholesterol diet groups and the brain levels of 27‑OHC significantly increased in the 1.6% cholesterol diet group. Increased concentration of cholesterol in the diet had no significant influence on plasma and brain levels of 24S‑OHC in the rats. In addition, Aβ1‑40 and Aβ1‑42 levels in plasma and brain were significantly elevated following administration of 0.5 and 1.6% diet cholesterol. The present study revealed that high diet cholesterol contributed to increased level of oxysterols, especially 27‑OHC, in the peripheral blood and the brain, which may be the link between increased peripheral cholesterol and brain Aβ production.
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January-2018
Volume 17 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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  • Journal Metrics
  • Impact Factor: 3.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 6.9
  • CiteScore Rank: Q2: #98/328 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.721
  • SCImago Journal Rank (SJR): 0.65
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Spandidos Publications style
Liu Q, An Y, Ma W, Feng L, Wang C, Lu Y and Xiao R: High‑cholesterol diet results in elevated amyloid‑β and oxysterols in rats. Mol Med Rep 17: 1235-1240, 2018
APA
Liu, Q., An, Y., Ma, W., Feng, L., Wang, C., Lu, Y., & Xiao, R. (2018). High‑cholesterol diet results in elevated amyloid‑β and oxysterols in rats. Molecular Medicine Reports, 17, 1235-1240. https://doi.org/10.3892/mmr.2017.8003
MLA
Liu, Q., An, Y., Ma, W., Feng, L., Wang, C., Lu, Y., Xiao, R."High‑cholesterol diet results in elevated amyloid‑β and oxysterols in rats". Molecular Medicine Reports 17.1 (2018): 1235-1240.
Chicago
Liu, Q., An, Y., Ma, W., Feng, L., Wang, C., Lu, Y., Xiao, R."High‑cholesterol diet results in elevated amyloid‑β and oxysterols in rats". Molecular Medicine Reports 17, no. 1 (2018): 1235-1240. https://doi.org/10.3892/mmr.2017.8003