Molecular mechanisms of autophagy in cardiac ischemia/reperfusion injury (Review)

  • Authors:
    • Xiao‑Long Lin
    • Wei‑Jin Xiao
    • Le‑Le Xiao
    • Mi‑Hua Liu
  • View Affiliations

  • Published online on: May 16, 2018     https://doi.org/10.3892/mmr.2018.9028
  • Pages: 675-683
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Abstract

Autophagy is a maintenance process for recycling long-lived proteins and cytoplasmic organelles. The level of this process is enhanced during ischemia/reperfusion (I/R) injury. Autophagy can trigger survival signaling in myocardial ischemia, whereas defective autophagy during reperfusion is detrimental. Autophagy can be regulated through multiple signaling pathways in I/R, including Beclin‑1/class III phosphatidylinositol‑3 kinase (PI‑3K), adenosine monophosphate activated protein kinase/mammalian target of rapamycin (mTOR), and PI‑3K/protein kinase B/mTOR pathways, which consequently lead to different functions. Thus, autophagy has both protective and detrimental functions, which are determined by different signaling pathways and conditions. Targeting the activation of autophagy can be a promising new therapeutic strategy for treating cardiovascular disease.
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July-2018
Volume 18 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Lin XL, Xiao WJ, Xiao LL and Liu MH: Molecular mechanisms of autophagy in cardiac ischemia/reperfusion injury (Review). Mol Med Rep 18: 675-683, 2018
APA
Lin, X., Xiao, W., Xiao, L., & Liu, M. (2018). Molecular mechanisms of autophagy in cardiac ischemia/reperfusion injury (Review). Molecular Medicine Reports, 18, 675-683. https://doi.org/10.3892/mmr.2018.9028
MLA
Lin, X., Xiao, W., Xiao, L., Liu, M."Molecular mechanisms of autophagy in cardiac ischemia/reperfusion injury (Review)". Molecular Medicine Reports 18.1 (2018): 675-683.
Chicago
Lin, X., Xiao, W., Xiao, L., Liu, M."Molecular mechanisms of autophagy in cardiac ischemia/reperfusion injury (Review)". Molecular Medicine Reports 18, no. 1 (2018): 675-683. https://doi.org/10.3892/mmr.2018.9028