Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
December-2018 Volume 18 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2018 Volume 18 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Syringaresinol‑di‑O‑β‑D‑glucoside, a phenolic compound from Polygonatum sibiricum, exhibits an antidiabetic and antioxidative effect on a streptozotocin‑induced mouse model of diabetes

  • Authors:
    • Liping Zhai
    • Xu Wang
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China
    Copyright: © Zhai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5511-5519
    |
    Published online on: October 23, 2018
       https://doi.org/10.3892/mmr.2018.9580
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Syringaresinol‑di‑O‑β‑D‑glucoside (SOG) is a phenolic compound extracted from Polygonatum sibiricum. The present study aimed to investigate the antidiabetic effect of SOG on streptozocin (STZ)‑induced diabetic mice and determine the potential underlying mechanisms. In the present study, fasting blood glucose and organ indexes of mice were analyzed. Body weight, water intake and food intake were also recorded. Furthermore, serum fasting insulin, pancreatic insulin and pancreatic interleukin‑6 levels of mice were determined using ELISA kits to investigate the effect of SOG on the levels of insulin. Levels of total cholesterol (TC), triglyceride (TG), high‑density lipoprotein cholesterol, low‑density lipoprotein cholesterol (LDL‑C), very low‑density lipoprotein cholesterol (VLDL‑C) and free fatty acid (FFA) in the serum of mice, and levels of TC, TG and total protein in the kidney, were also determined to investigate the effects of SOG on lipid and protein metabolism in mice. Furthermore, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) levels, as well as total antioxidant capacity (T‑AOC), in the kidneys of mice were determined to investigate the effect of SOG on oxidative stress. Western blotting was also performed to determine the expression of proteins associated with oxidative stress. The results demonstrated that SOG (25, 50 and 75 mg/kg) induced a significant antidiabetic effect in mice. Treatment with SOG promoted insulin secretion and decreased TC, TG, LDL‑C, VLDL‑C, FFA, MDA, SOD, CAT, AST, ALT and ALP levels in the kidneys of mice, as well as kidney TC and TG levels, but increased the levels of kidney total protein and the T‑AOC in kidneys. Furthermore, SOG treatment could significantly downregulate the expressions of nitrotyrosine and transforming growth factor‑β1 in diabetic mice. Therefore, the present study indicated that SOG may exert an antidiabetic effect on STZ‑induced diabetic mice and that the mechanism of SOG may be associated with its antioxidative activity.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Wild S, Roglic G, Green A, Sicree R and King H: Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030. Diabetes Care. 27:1047–1053. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Mrudula T, Suryanarayana P, Srinivas PN and Reddy GB: Effect of curcumin on hyperglycemia-induced vascular endothelial growth factor expression in streptozotocin-induced diabetic rat retina. Biochem Biophys Res Commun. 361:528–532. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Danaei G, Finucane MM, Lu Y, Singh GM, Cowan MJ, Paciorek CJ, Lin JK, Farzadfar F, Khang YH, Stevens GA, et al: National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: Systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants. Lancet. 378:31–40. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Ruiz-Ramos M, Escolar-Pujolar A, Mayoral-Sánchez E, Laureano Corral-San F and Fernández-Fernández I: Diabetes mellitus in Spain: Death rates, prevalence, impact, costs and inequalities. Gac Sanit. 20 Suppl 1:S15–S24. 2006. View Article : Google Scholar

5 

Kim SH, Hyun SH and Choung SY: Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice. J Ethnopharmacol. 104:119–123. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Ezeja MI, Anaga AO and Asuzu IU: Antidiabetic, antilipidemic, and antioxidant activities of Gouania longipetala methanol leaf extract in alloxan-induced diabetic rats. Pharm Biol. 53:605–614. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Reddy VP, Zhu X, Perry G and Smith MA: Oxidative stress in diabetes and Alzheimer's disease. J Alzheimers Dis. 16:763–774. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Huang J, Yang Y, Hu R and Chen L: Anti-interleukin-1 therapy has mild hypoglycaemic effect in type 2 diabetes. Diabetes Obes Metab. 20:1024–1028. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Li JY, Liu XM, Li B and Li M: Research progress in the symptom and treatment of diabetic nephropathy. Diabetes New World. 20:70–72. 2015.(In Chinese).

10 

Newman DJ and Cragg GM: Natural products as sources of new drugs from 1981 to 2014. J Nat Prod. 79:629–661. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Peng W, Shen W, Lin B, Han P, Li C, Zhang Q, Ye B, Rahman K, Xin H, Qin L and Han T: Docking study and antiosteoporosis effects of a dibenzylbutane lignan isolated from Litsea cubeba targeting Cathepsin K and MEK1. Med Chem Res. 27:2062–2070. 2018. View Article : Google Scholar

12 

Xie W and Du L: Diabetes is an inflammatory disease: Evidence from traditional Chinese medicines. Diabetes Obes Metab. 13:289–301. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Chinese Pharmacopoeia Commission, . Pharmacopoeia of the People's Republic of China Part IPeople's Medical Publishing House. Beijing: pp. 3062015

14 

Liu J, Zhang H, Ji B, Cai S, Wang R, Zhou F, Yang J and Liu H: A diet formula of Puerariae radix, Lycium barbarum, Crataegus pinnatifida, and Polygonati rhizoma alleviates insulin resistance and hepatic steatosis in CD-1 mice and HepG2 cells. Food Funct. 5:1038–1049. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Chen H, Feng SS, Sun YJ, Hao ZY, Feng WS and Zheng XK: Advances in studies on chemical constituents of three medicinal plants from Polygonatum Mill. and their pharmacological activities. Chin Tradit Herb Drugs. 46:2329–2338. 2015.

16 

National Institute of Health, . USA: Public health service policy on humane care and use of laboratory animals; 2002

17 

Jin DK: Antidiabetic effect of DMDD Isolated from Averrhoa carambola L. roots on STZ-induced diabetic mice and its potential mechanism (unpublished PhD thesis). Guangxi Medical University. 2014.

18 

Rakieten N, Rakieten ML and Nadkarni MV: Studies on the diabetogenic action of streptozotocin (NSC-37917). Cancer Chemother Rep. 29:91–98. 1963.

19 

Kintoko K and Huang R: Mechanism of insulin resistance in type 2 diabetes mellitus. Proceeding of International Symposium on Progress in Pharmacology. 2013.

20 

Russell DW: Cholesterol biosynthesis and metabolism. Cardiovasc Drugs Ther. 6:103–110. 1992. View Article : Google Scholar : PubMed/NCBI

21 

Ibrahim SRM, Mohamed GA, Banjar ZM and Kamal HKM: Natural antihyperlipidemic agents: Current status and future persepctives. Phytopharmacology. 4:492–531. 2013.

22 

Grundy SM, Cleeman JI, Rifkind BM and Kuller LH: Cholesterol lowering in the elderly population. Coordinating Committee of the National Cholesterol Education Program. Arch Intern Med. 159:1670–1678. 1999. View Article : Google Scholar : PubMed/NCBI

23 

Mahmood ZA, Ahmed SW, Sualeh M and Mahmood SBZ: Hyperlipidemia development and consequences. Med Channel. 5:14–17. 2009.

24 

Weng X: Research progress of treatment of diabetic nephropathy in traditional Chinese medicine. Asia-Pacific Tradit Med. 2:62–63. 2015.(In Chinese).

25 

Lv SQ, Zhang SF, Wang ZQ, Song HL, Han ZQ, Su XH, Liu AR, Wang YS, Yu WX and Chi XE: Protective effect of jianpi gushen huayu decoction on diabetic nephropathy rats. Chin J Exp Tradi Med Formulae. 24:142–147. 2018.

26 

Kim HJ, Lee SG, Chae IG, Kim MJ, Im NK, Yu MH, Lee EJ and Lee IS: Antioxidant effects of fermented red ginseng extract in streptozotocin-induced diabetic rats. J Ginseng Res. 35:129–137. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Kakkar R, Kalra J, Mantha SV and Prasad K: Lipid peroxidation and activity of antioxidant enzymes in diabetic rats. Mol Cell Biochem. 151:113–119. 1995. View Article : Google Scholar : PubMed/NCBI

28 

Manna P, Sinha M and Sil PC: Protective role of arjunolic acid in response to streptozotocin-induced type-1 diabetes via the mitochondria dependent and independent pathways. Toxicol. 257:53–63. 2009. View Article : Google Scholar

29 

Maritim AC, Sanders RA and Watkins JB III: Diabetes, oxidative stress, and antioxidant: A review. J Biochem Mol Toxicol. 17:24–38. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Winterbourne CC: Superoxide as intracellular radical sink. Free Radic Biol Med. 14:85–90. 1993. View Article : Google Scholar : PubMed/NCBI

31 

Sies H: Total antioxidant capacity: Appraisal of a concept. J Nutr. 137:1493–1495. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Okada M, Murakami Y and Miyamoto E: Glycation and inactivation of aspartate aminotransferase in diabetic rat tissues. J Nutr Sci Vitaminol (Tokyo). 43:463–469. 1997. View Article : Google Scholar : PubMed/NCBI

33 

Leibovitch I, Ben-Chaim J, Ramon J and Goldwasser B: Increased serum alkaline phosphatase activity: A possible indicator of renal damage. J Clin Lab Anal. 5:406–409. 1991. View Article : Google Scholar : PubMed/NCBI

34 

Ceriello A, Mercuri F, Quagliaro L, Assaloni R, Motz E, Tonutti L and Taboga C: Detection of nitrotyrosine in the diabetic plasma: Evidence of oxidative stress. Diabetologia. 44:834–838. 2001. View Article : Google Scholar : PubMed/NCBI

35 

Fang F, Wu YG, Dong J, Ren KJ, Qi XM, Liang C and Zhang W: Effects of total glucosides of paeony on oxidative stress in renal tissue of diabetic rats. Chin J Pharmacol Toxicol. 22:199–204. 2008.(In Chinese).

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhai L and Wang X: Syringaresinol‑di‑O‑β‑D‑glucoside, a phenolic compound from Polygonatum sibiricum, exhibits an antidiabetic and antioxidative effect on a streptozotocin‑induced mouse model of diabetes. Mol Med Rep 18: 5511-5519, 2018.
APA
Zhai, L., & Wang, X. (2018). Syringaresinol‑di‑O‑β‑D‑glucoside, a phenolic compound from Polygonatum sibiricum, exhibits an antidiabetic and antioxidative effect on a streptozotocin‑induced mouse model of diabetes. Molecular Medicine Reports, 18, 5511-5519. https://doi.org/10.3892/mmr.2018.9580
MLA
Zhai, L., Wang, X."Syringaresinol‑di‑O‑β‑D‑glucoside, a phenolic compound from Polygonatum sibiricum, exhibits an antidiabetic and antioxidative effect on a streptozotocin‑induced mouse model of diabetes". Molecular Medicine Reports 18.6 (2018): 5511-5519.
Chicago
Zhai, L., Wang, X."Syringaresinol‑di‑O‑β‑D‑glucoside, a phenolic compound from Polygonatum sibiricum, exhibits an antidiabetic and antioxidative effect on a streptozotocin‑induced mouse model of diabetes". Molecular Medicine Reports 18, no. 6 (2018): 5511-5519. https://doi.org/10.3892/mmr.2018.9580
Copy and paste a formatted citation
x
Spandidos Publications style
Zhai L and Wang X: Syringaresinol‑di‑O‑β‑D‑glucoside, a phenolic compound from Polygonatum sibiricum, exhibits an antidiabetic and antioxidative effect on a streptozotocin‑induced mouse model of diabetes. Mol Med Rep 18: 5511-5519, 2018.
APA
Zhai, L., & Wang, X. (2018). Syringaresinol‑di‑O‑β‑D‑glucoside, a phenolic compound from Polygonatum sibiricum, exhibits an antidiabetic and antioxidative effect on a streptozotocin‑induced mouse model of diabetes. Molecular Medicine Reports, 18, 5511-5519. https://doi.org/10.3892/mmr.2018.9580
MLA
Zhai, L., Wang, X."Syringaresinol‑di‑O‑β‑D‑glucoside, a phenolic compound from Polygonatum sibiricum, exhibits an antidiabetic and antioxidative effect on a streptozotocin‑induced mouse model of diabetes". Molecular Medicine Reports 18.6 (2018): 5511-5519.
Chicago
Zhai, L., Wang, X."Syringaresinol‑di‑O‑β‑D‑glucoside, a phenolic compound from Polygonatum sibiricum, exhibits an antidiabetic and antioxidative effect on a streptozotocin‑induced mouse model of diabetes". Molecular Medicine Reports 18, no. 6 (2018): 5511-5519. https://doi.org/10.3892/mmr.2018.9580
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team