Investigational drugs in HIV: Pros and cons of entry and fusion inhibitors (Review)

  • Authors:
    • Emmanuele Venanzi Rullo
    • Manuela Ceccarelli
    • Fabrizio Condorelli
    • Alessio Facciolà
    • Giuseppa Visalli
    • Francesco D'Aleo
    • Ivana Paolucci
    • Bruno Cacopardo
    • Marilia Rita Pinzone
    • Michele Di Rosa
    • Giuseppe Nunnari
    • Giovanni F. Pellicanò
  • View Affiliations

  • Published online on: January 10, 2019     https://doi.org/10.3892/mmr.2019.9840
  • Pages: 1987-1995
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Despite the profound changes and improvements reached in the field of HIV treatment, tolerability and adherence to highly active antiretroviral therapy remains a challenge. Furthermore, multi-experienced patients could take advantage of drugs with different mechanisms of action to combat the spread of resistance to actual therapy. For these reasons identification of new HIV drugs is crucial. Among all the molecules that at present are under investigation, entry and fusion inhibitors pose an interesting class owing to their peculiar characteristics, including prevention of entry of the virus into the human cells. In this study, we reviewed articles, clinical trials, and conference communications about all the drugs under investigation belonging to the class of entry and fusion inhibitors that are at least in phase I clinical trials.
View Figures
View References

Related Articles

Journal Cover

March-2019
Volume 19 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Venanzi Rullo E, Ceccarelli M, Condorelli F, Facciolà A, Visalli G, D'Aleo F, Paolucci I, Cacopardo B, Pinzone MR, Di Rosa M, Di Rosa M, et al: Investigational drugs in HIV: Pros and cons of entry and fusion inhibitors (Review). Mol Med Rep 19: 1987-1995, 2019
APA
Venanzi Rullo, E., Ceccarelli, M., Condorelli, F., Facciolà, A., Visalli, G., D'Aleo, F. ... Pellicanò, G.F. (2019). Investigational drugs in HIV: Pros and cons of entry and fusion inhibitors (Review). Molecular Medicine Reports, 19, 1987-1995. https://doi.org/10.3892/mmr.2019.9840
MLA
Venanzi Rullo, E., Ceccarelli, M., Condorelli, F., Facciolà, A., Visalli, G., D'Aleo, F., Paolucci, I., Cacopardo, B., Pinzone, M. R., Di Rosa, M., Nunnari, G., Pellicanò, G. F."Investigational drugs in HIV: Pros and cons of entry and fusion inhibitors (Review)". Molecular Medicine Reports 19.3 (2019): 1987-1995.
Chicago
Venanzi Rullo, E., Ceccarelli, M., Condorelli, F., Facciolà, A., Visalli, G., D'Aleo, F., Paolucci, I., Cacopardo, B., Pinzone, M. R., Di Rosa, M., Nunnari, G., Pellicanò, G. F."Investigational drugs in HIV: Pros and cons of entry and fusion inhibitors (Review)". Molecular Medicine Reports 19, no. 3 (2019): 1987-1995. https://doi.org/10.3892/mmr.2019.9840