Role of PPARs in inflammatory processes associated with metabolic syndrome (Review)

  • Authors:
    • Eduardo Fuentes
    • Luis Guzmán-Jofre
    • Rodrigo Moore-Carrasco
    • Iván Palomo
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  • Published online on: October 7, 2013     https://doi.org/10.3892/mmr.2013.1714
  • Pages: 1611-1616
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Abstract

Metabolic syndrome (MS) includes the presence of arterial hypertension, insulin resistance, dyslipidemia, cardiovascular disease (CVD) and abdominal obesity, which is associated with a chronic inflammatory response, characterized by abnormal adipokine production, and the activation of certain pro-inflammatory signaling pathways. Furthermore, the changes presented by the adipose tissue in MS favors the secretion of several molecular mediators capable of activating or suppressing a number of transcription factors, such as the peroxisome proliferator-activated receptors (PPARs), whose main functions include storage regulation and fatty acid catabolization. When they are activated by their ligands (synthetic or endogenous), they control several genes involved in intermediate metabolism, which make them, together with the PPAR gamma coactivator-1-α (PGC-1) and the silent information regulator T1 (SIRT1), good targets for treating metabolic diseases and their cardiovascular complications.
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December 2013
Volume 8 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Fuentes E, Guzmán-Jofre L, Moore-Carrasco R and Palomo I: Role of PPARs in inflammatory processes associated with metabolic syndrome (Review). Mol Med Rep 8: 1611-1616, 2013
APA
Fuentes, E., Guzmán-Jofre, L., Moore-Carrasco, R., & Palomo, I. (2013). Role of PPARs in inflammatory processes associated with metabolic syndrome (Review). Molecular Medicine Reports, 8, 1611-1616. https://doi.org/10.3892/mmr.2013.1714
MLA
Fuentes, E., Guzmán-Jofre, L., Moore-Carrasco, R., Palomo, I."Role of PPARs in inflammatory processes associated with metabolic syndrome (Review)". Molecular Medicine Reports 8.6 (2013): 1611-1616.
Chicago
Fuentes, E., Guzmán-Jofre, L., Moore-Carrasco, R., Palomo, I."Role of PPARs in inflammatory processes associated with metabolic syndrome (Review)". Molecular Medicine Reports 8, no. 6 (2013): 1611-1616. https://doi.org/10.3892/mmr.2013.1714