BMI‑1, a promising therapeutic target for human cancer (Review)

  • Authors:
    • Min‑Cong Wang
    • Chun‑Li Li
    • Jie Cui
    • Min Jiao
    • Tao Wu
    • Li Jing
    • Ke‑Jun Nan
  • View Affiliations

  • Published online on: June 11, 2015     https://doi.org/10.3892/ol.2015.3361
  • Pages: 583-588
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Abstract

BMI‑1 oncogene is a member of the polycomb‑group gene family and a transcriptional repressor. Overexpression of BMI‑1 has been identified in various human cancer tissues and is known to be involved in cancer cell proliferation, cell invasion, distant metastasis, chemosensitivity and patient survival. Accumulating evidence has revealed that BMI‑1 is also involved in the regulation of self‑renewal, differentiation and tumor initiation of cancer stem cells (CSCs). However, the molecular mechanisms underlying these biological processes remain unclear. The present review summarized the function of BMI‑1 in different human cancer types and CSCs, and discussed the signaling pathways in which BMI‑1 is potentially involved. In conclusion, BMI‑1 may represent a promising target for the prevention and therapy of various cancer types.
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August-2015
Volume 10 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Wang MC, Li CL, Cui J, Jiao M, Wu T, Jing L and Nan KJ: BMI‑1, a promising therapeutic target for human cancer (Review). Oncol Lett 10: 583-588, 2015
APA
Wang, M., Li, C., Cui, J., Jiao, M., Wu, T., Jing, L., & Nan, K. (2015). BMI‑1, a promising therapeutic target for human cancer (Review). Oncology Letters, 10, 583-588. https://doi.org/10.3892/ol.2015.3361
MLA
Wang, M., Li, C., Cui, J., Jiao, M., Wu, T., Jing, L., Nan, K."BMI‑1, a promising therapeutic target for human cancer (Review)". Oncology Letters 10.2 (2015): 583-588.
Chicago
Wang, M., Li, C., Cui, J., Jiao, M., Wu, T., Jing, L., Nan, K."BMI‑1, a promising therapeutic target for human cancer (Review)". Oncology Letters 10, no. 2 (2015): 583-588. https://doi.org/10.3892/ol.2015.3361