Applications of nanoparticle drug delivery systems for the reversal of multidrug resistance in cancer (Review)

  • Authors:
    • Yinghong Huang
    • Susan P.C. Cole
    • Tiange Cai
    • Yu Cai
  • View Affiliations

  • Published online on: May 17, 2016     https://doi.org/10.3892/ol.2016.4596
  • Pages: 11-15
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Abstract

Multidrug resistance (MDR) to chemotherapy presents a major obstacle in the treatment of cancer patients, which directly affects the clinical success rate of cancer therapy. Current research aims to improve the efficiency of chemotherapy, whilst reducing toxicity to prolong the lives of cancer patients. As with good biocompatibility, high stability and drug release targeting properties, nanodrug delivery systems alter the mechanism by which drugs function to reverse MDR, via passive or active targeting, increasing drug accumulation in the tumor tissue or reducing drug elimination. Given the potential role of nanodrug delivery systems used in multidrug resistance, the present study summarizes the current knowledge on the properties of liposomes, lipid nanoparticles, polymeric micelles and mesoporous silica nanoparticles, together with their underlying mechanisms. The current review aims to provide a reliable basis and useful information for the development of new treatment strategies of multidrug resistance reversal using nanodrug delivery systems.
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July-2016
Volume 12 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Huang Y, Cole SP, Cai T and Cai Y: Applications of nanoparticle drug delivery systems for the reversal of multidrug resistance in cancer (Review). Oncol Lett 12: 11-15, 2016
APA
Huang, Y., Cole, S.P., Cai, T., & Cai, Y. (2016). Applications of nanoparticle drug delivery systems for the reversal of multidrug resistance in cancer (Review). Oncology Letters, 12, 11-15. https://doi.org/10.3892/ol.2016.4596
MLA
Huang, Y., Cole, S. P., Cai, T., Cai, Y."Applications of nanoparticle drug delivery systems for the reversal of multidrug resistance in cancer (Review)". Oncology Letters 12.1 (2016): 11-15.
Chicago
Huang, Y., Cole, S. P., Cai, T., Cai, Y."Applications of nanoparticle drug delivery systems for the reversal of multidrug resistance in cancer (Review)". Oncology Letters 12, no. 1 (2016): 11-15. https://doi.org/10.3892/ol.2016.4596