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Article

Synchronous ovarian metastasis from colorectal cancer: A report of two cases

  • Authors:
    • Jiro Shimazaki
    • Takanobu Tabuchi
    • Kiyotaka Nishida
    • Akira Takemura
    • Gyo Motohashi
    • Hideki Kajiyama
    • Shuji Suzuki
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterological Surgery, Ibaraki Medical Center, Tokyo Medical University, Inashiki, Ibaraki 300‑0395, Japan
  • Pages: 257-261
    |
    Published online on: May 11, 2016
       https://doi.org/10.3892/ol.2016.4553
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Abstract

Ovarian metastasis of colorectal cancer is relatively rare. The present study reports two cases of synchronous ovarian metastasis from colorectal cancer, which were managed by cytoreductive surgery. In case one, a 60-year-old female patient presented with a multilocular pelvic tumor and ascites. Virtual colonoscopy revealed a mass in the sigmoid colon; however, no tumor cells were identified on histological examination. Ovarian metastasis from sigmoid colon cancer was suspected and adnexectomy was subsequently performed. Histological examination of the excised tumor revealed adenocarcinoma. Immunohistochemical analysis of the resected tumor revealed positive staining for cytokeratin (CK)20 and caudal‑type homeobox 2 (CDX2), and negative staining for CK7, estrogen receptor, progesterone receptor and inhibin. The immunohistological results supported the diagnosis of ovarian metastasis from sigmoid colon cancer. In case two, a 56‑year‑old female patient presented with a multilocular pelvic tumor and ascites. Colonoscopy identified a rectal tumor, and histological examination revealed moderately‑differentiated adenocarcinoma, which was confirmed by cytological analysis of ascites. Subsequently, ovarian metastasis from rectal cancer with peritoneal dissemination was diagnosed, and left ovariectomy and transverse colostomy were performed. Histological examination of the excised tumor revealed moderately‑differentiated adenocarcinoma, and immunohistochemical investigation revealed positive staining for CK20 and CDX2, but negative staining for CK7. These immunohistological results indicated ovarian metastasis from rectal cancer. Both patients recovered well and are currently undergoing regular follow‑up examinations. The observations from the two cases indicate that ovarian metastases of primary colorectal cancer may present as pelvic tumors and, thus, preoperative examination of the gastrointestinal tract is required. Furthermore, even in cases of widespread colorectal cancer metastases, excision of the ovarian tumor is required to establish a histological diagnosis for the selection of appropriate treatments.
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Copy and paste a formatted citation
Spandidos Publications style
Shimazaki J, Tabuchi T, Nishida K, Takemura A, Motohashi G, Kajiyama H and Suzuki S: Synchronous ovarian metastasis from colorectal cancer: A report of two cases. Oncol Lett 12: 257-261, 2016.
APA
Shimazaki, J., Tabuchi, T., Nishida, K., Takemura, A., Motohashi, G., Kajiyama, H., & Suzuki, S. (2016). Synchronous ovarian metastasis from colorectal cancer: A report of two cases. Oncology Letters, 12, 257-261. https://doi.org/10.3892/ol.2016.4553
MLA
Shimazaki, J., Tabuchi, T., Nishida, K., Takemura, A., Motohashi, G., Kajiyama, H., Suzuki, S."Synchronous ovarian metastasis from colorectal cancer: A report of two cases". Oncology Letters 12.1 (2016): 257-261.
Chicago
Shimazaki, J., Tabuchi, T., Nishida, K., Takemura, A., Motohashi, G., Kajiyama, H., Suzuki, S."Synchronous ovarian metastasis from colorectal cancer: A report of two cases". Oncology Letters 12, no. 1 (2016): 257-261. https://doi.org/10.3892/ol.2016.4553
Copy and paste a formatted citation
x
Spandidos Publications style
Shimazaki J, Tabuchi T, Nishida K, Takemura A, Motohashi G, Kajiyama H and Suzuki S: Synchronous ovarian metastasis from colorectal cancer: A report of two cases. Oncol Lett 12: 257-261, 2016.
APA
Shimazaki, J., Tabuchi, T., Nishida, K., Takemura, A., Motohashi, G., Kajiyama, H., & Suzuki, S. (2016). Synchronous ovarian metastasis from colorectal cancer: A report of two cases. Oncology Letters, 12, 257-261. https://doi.org/10.3892/ol.2016.4553
MLA
Shimazaki, J., Tabuchi, T., Nishida, K., Takemura, A., Motohashi, G., Kajiyama, H., Suzuki, S."Synchronous ovarian metastasis from colorectal cancer: A report of two cases". Oncology Letters 12.1 (2016): 257-261.
Chicago
Shimazaki, J., Tabuchi, T., Nishida, K., Takemura, A., Motohashi, G., Kajiyama, H., Suzuki, S."Synchronous ovarian metastasis from colorectal cancer: A report of two cases". Oncology Letters 12, no. 1 (2016): 257-261. https://doi.org/10.3892/ol.2016.4553
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