Invasive micropapillary component and its clinico-histopathological significance in patients with colorectal cancer

Jakubowska,Katarzyna; Guzińska‑Ustymowicz,Katarzyna; Pryczynicz,Anna

doi:10.3892/ol.2016.4717

Invasive micropapillary component and its clinico-histopathological significance in patients with colorectal cancer

Authors:
- Katarzyna Jakubowska
- Katarzyna Guzińska‑Ustymowicz
- Anna Pryczynicz
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Affiliations: Department of General Pathomorphology, Medical University of Białystok, Białystok, 15-269 Podlaskie, Poland
Published online on: June 15, 2016 https://doi.org/10.3892/ol.2016.4717
Pages: 1154-1158

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Abstract

Micropapillary components are located in distinct, empty spaces resembling lymphatic vessels and consist of clusters of cancer cells that adhere tightly to one another. These structures do not have a fibrovascular core. Invasive micropapillary components (IMPCs) exhibit reverse polarity, which results in a characteristic ‘inside‑out’ structure. The aim of the present study was to examine the histological significance of the micropapillary component in colorectal carcinoma compared with conventional colorectal adenocarcinoma. Among 115 patients, 5 (4.3%) were diagnosed with a micropapillary colorectal component based on hematoxylin and eosin staining and immunohistochemical analysis. To exclude identification of poorly‑differentiated clusters of adenocarcinoma cells in the lymphatic vessels, immunohistochemical analysis with D2‑40 was performed, and epithelial membrane antigen was used to confirm the specific ‘inside‑out’ structure of IMPCs. IMPCs were observed to positively correlate with histopathological type (P=0.001) and tumor invasion in venous vessels (P=0.033). Furthermore, the presence and number of lymph node metastases was greater in IMPC cases compared with conventional carcinoma cases; however, these differences were not statistically significant (P=0.087 and P=0.094, respectively). In addition, IMPC cases were not significantly associated with the presence of inflammatory infiltrate in the invasive front of the tumor (P=0.098). Therefore, the present study indicates that the IMPC serves a histopathological and prognostic role in the diagnosis of colorectal cancer due to its aggressive and invasive behavior. IMPC is rare in cases of colorectal cancer and remains a great diagnostic challenge in pathomorphology with further detailed investigation required in the future.

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1	Sonoo H, Kameyama M, Inatugi N, Nonomura A and Enomoto Y: Pedunculated polyp of early sigmoid colon cancer with invasive micropapillary carcinoma. Jpn J Clin Oncol. 39:523–527. 2009. View Article : Google Scholar : PubMed/NCBI
2	Kondo T: Colon invasive micropapillary carcinoma arising in tubulovillous adenoma. Pol J Pathol. 59:183–185. 2008.PubMed/NCBI
3	Sakamoto K, Watanabe M, De La Cruz C, Honda H, Ise H, Mitsui K, Namiki K, Mikami Y, Moriya T and Sasano H: Primary invasive micropapillary carcinoma of the colon. Histopathology. 47:479–484. 2005. View Article : Google Scholar : PubMed/NCBI
4	Ushiku T, Matsusaka K, Iwasaki Y, Tateishi Y, Funata N, Seto Y and Fukayama M: Gastric carcinoma with invasive micropapillary pattern and its association with lymph node metastasis. Histopathology. 59:1081–1089. 2011. View Article : Google Scholar : PubMed/NCBI
5	Wen P, Xu Y, Frankel WL and Shen R: Invasive micropapillary carcinoma of the sigmoid colon: Distinct morphology and aggressive behavior. Int J Clin Exp Pathol. 1:457–460. 2008.PubMed/NCBI
6	Verdú M, Román R, Calvo M, Rodón N, García B, González M, Vidal A and Puig X: Clinicopathological and molecular characterization of colorectal micropapillary carcinoma. Mod Pathol. 24:729–738. 2011. View Article : Google Scholar : PubMed/NCBI
7	Haupt B, Ro JY, Schwartz MR and Shen SS: Colorectal adenocarcinoma with micropapillary pattern and its association with lymph node metastasis. Mod Pathol. 20:729–733. 2007. View Article : Google Scholar : PubMed/NCBI
8	Lino-Silva LS: Pure micropapillary rectal carcinoma with CK7 and CK20 coexpression and loss of CDX2 reactivity. Int J Morphol. 30:25–29. 2012. View Article : Google Scholar
9	Ohtsuki Y, Kuroda N, Yunoki S, Murakami S, Mizukami Y, Okada Y, Iguchi M, Lee GH and Furihata M: Immunohistochemical analysis of invasive micropapillary carcinoma pattern in four cases of gastric cancer. Med Mol Morphol. 46:114–121. 2013. View Article : Google Scholar : PubMed/NCBI
10	Seidman JD and Kurman RJ: Subclassification of serous borderline tumors of the ovary into benign and malignant types. A clinicopathologic study of 65 advanced stage cases. Am J Surg Pathol. 20:1331–1345. 1996. View Article : Google Scholar : PubMed/NCBI
11	Luna-Moré S, Gonzalez B, Acedo C, Rodrigo I and Luna C: Invasive micropapillary carcinoma of the breast. A new special type of invasive mammary carcinoma. Pathol Res Pract. 190:668–674. 1994. View Article : Google Scholar : PubMed/NCBI
12	Li YS, Kaneko M, Sakamoto DG, Takeshima Y and Inai K: The reversed apical pattern of MUC1 expression is characteristics of invasive micropapillary carcinoma of the breast. Breast Cancer. 13:58–63. 2006. View Article : Google Scholar : PubMed/NCBI
13	Siriaunkgul S and Tavassoli FA: Invasive micropapillary carcinoma of the breast. Mod Pathol. 6:660–662. 1993.PubMed/NCBI
14	Amin MB, Ro JY, el-Sharkawy T, Lee KM, Troncoso P, Silva EG, Ordóñez NG and Ayala AG: Micropapillary variant of transitional cell carcinoma of the urinary bladder. Histologic pattern resembling ovarian papillary serous carcinoma. Am J Surg Pathol. 18:1224–1232. 1994. View Article : Google Scholar : PubMed/NCBI
15	Amin MB, Tamboli P, Merchant SH, Ordóñez NG, Ro J, Ayala AG and Ro JY: Micropapillary component in lung adenocarcinoma: A distinctive histologic feature with possible prognostic significance. Am J Surg Pathol. 26:358–364. 2002. View Article : Google Scholar : PubMed/NCBI
16	Nagao T, Gaffey TA, Visscher DW, Kay PA, Minato H, Serizawa H and Lewis JE: Invasive micropapillary salivary duct carcinoma: A distinct histologic variant with biologic significance. Am J Surg Pathol. 28:319–326. 2004. View Article : Google Scholar : PubMed/NCBI
17	Laurent I, Uzan C, Gouy S, Pautier P, Duvillard P and Morice P: Results after conservative treatment of serous borderline tumors of the ovary with a micropapillary pattern. Ann Surg Oncol. 15:3561–3566. 2008. View Article : Google Scholar : PubMed/NCBI
18	Kuroda N, Oonishi K, Ohara M, Hirouchi T, Mizuno K, Hayashi Y and Lee GH: Invasive micropapillary carcinoma of the colon: An immunohistochemical study. Med Mol Morphol. 40:226–230. 2007. View Article : Google Scholar : PubMed/NCBI
19	Hamilton SR, Rubio CA, Vogelstein B, Sobin LH, Kudo S, Fogt F, Riboli E, Winawer SJ, Nakamura S, Goldgar DE, et al: Tumours of the colon and rectum: Carcinoma of the colon and rectum. World Health Organization Classification of Tumours - Pathology and Genetics of Tumours of the Digestive System. Hamilton SR and Aaltonen LA: IARC Press; Lyon, France: pp. 104–110. 2000
20	Kim MJ, Hong SM, Jang SJ, Yu E, Kim JS, Kim KR, Gong G and Ro JY: Invasive colorectal micropapillary carcinoma: An aggressive variant of adenocarcinoma. Hum Pathol. 37:809–815. 2006. View Article : Google Scholar : PubMed/NCBI
21	Lino-Silva LS, Salcedo-Hernández RA and Caro-Sánchez CH: Colonic micropapillary carcinoma, a recently recognized subtype associated with histological adverse factors: Clinicopathological analysis of 15 cases. Colorectal Dis. 14:e567–e572. 2012. View Article : Google Scholar : PubMed/NCBI
22	Xu F, Xu J, Lou Z, Di M, Wang F, Hu H and Lai M: Micropapillary component in colorectal carcinoma is associated with lymph node metastasis in T1 and T2 Stages and decreased survival time in TNM stages I and II. Am J Surg Pathol. 33:1287–1292. 2009. View Article : Google Scholar : PubMed/NCBI
23	Wesseling J, van der Valk SW, Vos HL, Sonnenberg A and Hilkens J: Episialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix components. J Cell Biol. 129:255–265. 1995. View Article : Google Scholar : PubMed/NCBI
24	Khayyata S, Basturk O and Adsay NV: Invasive micropapillary carcinomas of the ampullo-pancreatobiliary region and their association with tumor-infiltrating neutrophils. Mod Pathol. 18:1504–1511. 2005. View Article : Google Scholar : PubMed/NCBI