Open Access

High expression of TRPM8 predicts poor prognosis in patients with osteosarcoma

  • Authors:
    • Wei Zhao
    • Huimian Xu
  • View Affiliations

  • Published online on: June 22, 2016     https://doi.org/10.3892/ol.2016.4764
  • Pages: 1373-1379
  • Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The transient receptor potential melastatin member 8 (TRPM8) is a newly characterized oncoprotein involved in various malignant tumors. However, its expression pattern and biological function in osteosarcoma remain unclear. The present study aimed to explore the expression and prognostic significance of TRPM8 in osteosarcoma (OS). The results revealed that the expression of TRPM8 mRNA and protein in OS tissue was significantly higher than that in paired normal bone tissue (P<0.05). Additionally, the level of TRPM8 mRNA and protein in patients with a higher clinical stage and with distant metastasis was markedly higher than in those with a lower clinical stage and no metastasis (P<0.05). Furthermore, a high TRPM8 level was closely associated with clinical stage and distant metastasis (P=0.007 and 0.030), but not associated with the patient age (P=0.481), gender (P=0.905), tumor size (P=0.429), histological subtype (P=0.207) or anatomical location (P=0.369). In addition, OS patients with high TRPM8 expression had significantly shorter overall survival (P=0.008) and disease‑free survival times (P=0.008) when compared with patients with low expression of TRPM8. In Cox multivariate analysis, TRPM8 overexpression was identified to be an independent and significant prognostic factor for overall survival (P=0.040), but not for disease‑free survival (P=0.051). Collectively, the present data suggest that TRPM8 may play a crucial role in the development and progression of OS, and thus may be considered as a novel molecular target for therapy in patients with OS.
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August-2016
Volume 12 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhao W and Zhao W: High expression of TRPM8 predicts poor prognosis in patients with osteosarcoma. Oncol Lett 12: 1373-1379, 2016
APA
Zhao, W., & Zhao, W. (2016). High expression of TRPM8 predicts poor prognosis in patients with osteosarcoma. Oncology Letters, 12, 1373-1379. https://doi.org/10.3892/ol.2016.4764
MLA
Zhao, W., Xu, H."High expression of TRPM8 predicts poor prognosis in patients with osteosarcoma". Oncology Letters 12.2 (2016): 1373-1379.
Chicago
Zhao, W., Xu, H."High expression of TRPM8 predicts poor prognosis in patients with osteosarcoma". Oncology Letters 12, no. 2 (2016): 1373-1379. https://doi.org/10.3892/ol.2016.4764