White blood cell and platelet indices as prognostic markers in patients with invasive ductal breast carcinoma

  • Authors:
    • Dimitrios Mantas
    • Ioannis D. Kostakis
    • Nikolaos Machairas
    • Christos Markopoulos
  • View Affiliations

  • Published online on: June 22, 2016     https://doi.org/10.3892/ol.2016.4760
  • Pages: 1610-1614
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

A growing body of evidence suggests that oncogenesis is associated with systemic inflammation. The present study investigated white blood cell and platelet indices, whose values change during the inflammatory response, in women with invasive ductal breast carcinoma. Preoperatively obtained white blood cell and platelet counts from 53 patients with early breast cancer, who developed systemic metastases over a mean follow‑up period of 65 months, were analyzed and compared with those of a matching control group formed of 37 patients with the same characteristics, who remained recurrence‑free during the same time period. Patients who developed distant metastasis had a significantly higher mean platelet volume and lower neutrophil count than patients who did not present with distant metastasis. Furthermore, time to distant metastasis development was longer in patients with a lower mean platelet volume, whilst patients with a lower neutrophil count had a shorter systemic disease‑free time interval. However, receiver operating characteristic curve analysis demonstrated that these parameters provided moderate accuracy in predicting which patients may develop distant metastasis. No differences were detected between patient groups regarding additional parameters. Patients who developed systemic disease during a mean follow‑up period of 65 months were observed to have an increased mean platelet volume and decreased neutrophil count preoperatively. These results indicate that such parameters may be of prognostic value in patients with breast cancer. Studies with a larger number of patients are required to further investigate this hypothesis.

References

1 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer Clin. 64:9–29. 2014. View Article : Google Scholar

2 

Giraldo NA, Becht E, Vano Y, Sautès-Fridman C and Fridman WH: The immune response in cancer: From immunology to pathology to immunotherapy. Virchows Arch. 467:127–135. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Wu Y, Fu X, Zhu X, He X, Zou C, Han Y, Xu M, Huang C, Lu X and Zhao Y: Prognostic role of systemic inflammatory response in renal cell carcinoma: A systematic review and meta-analysis. J Cancer Res Clin Oncol. 137:887–896. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Menter DG, Tucker SC, Kopetz S, Sood AK, Crissman JD and Honn KV: Platelets and cancer: A casual or causal relationship: Revisited. Cancer Metastasis Rev. 33:231–269. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Yan M and Jurasz P: The role of platelets in the tumor microenvironment: From solid tumors to leukemia. Biochim Biophys Acta. 1863:392–400. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Franco AT, Corken A and Ware J: Platelets at the interface of thrombosis, inflammation, and cancer. Blood. 126:582–588. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Templeton AJ, McNamara MG, Šeruga B, Vera-Badillo FE, Aneja P, Ocaña A, Leibowitz-Amit R, Sonpavde G, Knox JJ, Tran B, et al: Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: A systematic review and meta-analysis. J Natl Cancer Inst. 106:dju1242014. View Article : Google Scholar : PubMed/NCBI

8 

Paramanathan A, Saxena A and Morris DL: A systematic review and meta-analysis on the impact of pre-operative neutrophil lymphocyte ratio on long term outcomes after curative intent resection of solid tumours. Surg Oncol. 23:31–39. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Xin-Ji Z, Yong-Gang L, Xiao-Jun S, Xiao-Wu C, Dong Z and Da-Jian Z: The prognostic role of neutrophils to lymphocytes ratio and platelet count in gastric cancer: A meta-analysis. Int J Surg. 21:84–91. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Templeton AJ, Ace O, McNamara MG, Al-Mubarak M, Vera-Badillo FE, Hermanns T, Seruga B, Ocaña A, Tannock IF and Amir E: Prognostic role of platelet to lymphocyte ratio in solid tumors: A systematic review and meta-analysis. Cancer Epidemiol Biomarkers Prev. 23:1204–1212. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Sobin LH, Gospodarowicz MK and Wittekind CH: Breast tumours. TNM Classification of Malignant Tumours (7th). Wiley-Blackwell. (Chichester, West Sussex, UK). 181–193. 2010.

12 

Ozyalvacli G, Yesil C, Kargi E, Kizildag B, Kilitci A and Yilmaz F: Diagnostic and prognostic importance of the neutrophil lymphocyte ratio in breast cancer. Asian Pac J Cancer Prev. 15:10363–10366. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Dirican A, Kucukzeybek BB, Alacacioglu A, Kucukzeybek Y, Erten C, Varol U, Somali I, Demir L, Bayoglu IV, Yildiz Y, et al: Do the derived neutrophil to lymphocyte ratio and the neutrophil to lymphocyte ratio predict prognosis in breast cancer? Int J Clin Oncol. 20:70–81. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Jia W, Wu J, Jia H, Yang Y, Zhang X, Chen K and Su F: The peripheral blood neutrophil-to-lymphocyte ratio is superior to the lymphocyte-to-monocyte ratio for predicting the long-term survival of triple-negative breast cancer patients. PLoS One. 10:e01430612015. View Article : Google Scholar : PubMed/NCBI

15 

Azab B, Shah N, Radbel J, Tan P, Bhatt V, Vonfrolio S, Habeshy A, Picon A and Bloom S: Pretreatment neutrophil/lymphocyte ratio is superior to platelet/lymphocyte ratio as a predictor of long-term mortality in breast cancer patients. Med Oncol. 30:4322013. View Article : Google Scholar : PubMed/NCBI

16 

Koh CH, Bhoo-Pathy N, Ng KL, Jabir RS, Tan GH, See MH, Jamaris S and Taib NA: Utility of pre-treatment neutrophil-lymphocyte ratio and platelet-lymphocyte ratio as prognostic factors in breast cancer. Br J Cancer. 113:150–158. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Noh H, Eomm M and Han A: Usefulness of pretreatment neutrophil to lymphocyte ratio in predicting disease-specific survival in breast cancer patients. J Breast Cancer. 16:55–59. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Yao M, Liu Y, Jin H, Liu X, Lv K, Wei H, Du C, Wang S, Wei B and Fu P: Prognostic value of preoperative inflammatory markers in Chinese patients with breast cancer. Onco Targets Ther. 7:1743–1752. 2014.PubMed/NCBI

19 

Koh YW, Lee HJ, Ahn JH, Lee JW and Gong G: Prognostic significance of the ratio of absolute neutrophil to lymphocyte counts for breast cancer patients with ER/PR-positivity and HER2-negativity in neoadjuvant setting. Tumour Biol. 35:9823–9830. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Ulas A, Avci N, Kos T, Cubukcu E, Olmez OF, Bulut N and Degirmenci M: Are neutrophil/lymphocyte ratio and platelet/lymphocyte ratio associated with prognosis in patients with HER2-positive early breast cancer receiving adjuvant trastuzumab? J BUON. 20:714–722. 2015.PubMed/NCBI

21 

Krenn-Pilko S, Langsenlehner U, Thurner EM, Stojakovic T, Pichler M, Gerger A, Kapp KS and Langsenlehner T: The elevated preoperative platelet-to-lymphocyte ratio predicts poor prognosis in breast cancer patients. Br J Cancer. 110:2524–2530. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Seretis C, Seretis F, Lagoudianakis E, Politou M, Gemenetzis G and Salemis NS: Enhancing the accuracy of platelet to lymphocyte ratio after adjustment for large platelet count: A pilot study in breast cancer patients. Int J Surg Oncol. 2012:6536082012.PubMed/NCBI

23 

Gu M, Zhai Z, Huang L, Zheng W, Zhou Y, Zhu R, Shen F and Yuan C: Pre-treatment mean platelet volume associates with worse clinicopathologic features and prognosis of patients with invasive breast cancer. Breast Cancer. Aug 26–2015.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

Related Articles

Journal Cover

August 2016
Volume 12 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Mantas, D., Kostakis, I.D., Machairas, N., & Markopoulos, C. (2016). White blood cell and platelet indices as prognostic markers in patients with invasive ductal breast carcinoma. Oncology Letters, 12, 1610-1614. https://doi.org/10.3892/ol.2016.4760
MLA
Mantas, D., Kostakis, I. D., Machairas, N., Markopoulos, C."White blood cell and platelet indices as prognostic markers in patients with invasive ductal breast carcinoma". Oncology Letters 12.2 (2016): 1610-1614.
Chicago
Mantas, D., Kostakis, I. D., Machairas, N., Markopoulos, C."White blood cell and platelet indices as prognostic markers in patients with invasive ductal breast carcinoma". Oncology Letters 12, no. 2 (2016): 1610-1614. https://doi.org/10.3892/ol.2016.4760