Clinicopathological relevance of kinesin family member 18A expression in invasive breast cancer

  • Authors:
    • Mai Kasahara
    • Makoto Nagahara
    • Tsuyoshi Nakagawa
    • Toshiaki Ishikawa
    • Takanobu Sato
    • Hiroyuki Uetake
    • Kenichi Sugihara
  • View Affiliations

  • Published online on: July 7, 2016     https://doi.org/10.3892/ol.2016.4823
  • Pages: 1909-1914
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Abstract

Recently, kinesin motor proteins have been focused on as targets for cancer therapy. Kinesins are microtubule‑based motor proteins that mediate diverse functions within the cell, including the transport of vesicles, organelles, chromosomes and protein complexes, as well as the movement of microtubules. In the current study, the expression of kinesin family member 18A (KIF18A), a member of kinesin superfamily, was investigated in breast cancer using immunohistochemistry, and its effect on breast cancer prognosis was examined. KIF18A expression level was significantly associated with lymph node metastasis (P=0.047). In patients with high levels of KIF18A expression, survival was significantly poorer compared to patients with low levels of KIF18A expression (disease‑free survival, P=0.030). Multivariate analysis revealed that venous invasion (hazard ratio, 9.22; 95% confidence interval, 3.90‑23.66; P<0.001) and KIF18A expression (hazard ratio, 3.20; 95% confidence interval, 1.34‑6.09; P=0.010) were independent predictive factors for lymph node metastasis. KIF18A may be a useful predictive marker for lymph node metastasis in breast cancer, which could facilitate curative adjuvant treatment.
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September-2016
Volume 12 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Kasahara M, Nagahara M, Nakagawa T, Ishikawa T, Sato T, Uetake H and Sugihara K: Clinicopathological relevance of kinesin family member 18A expression in invasive breast cancer. Oncol Lett 12: 1909-1914, 2016
APA
Kasahara, M., Nagahara, M., Nakagawa, T., Ishikawa, T., Sato, T., Uetake, H., & Sugihara, K. (2016). Clinicopathological relevance of kinesin family member 18A expression in invasive breast cancer. Oncology Letters, 12, 1909-1914. https://doi.org/10.3892/ol.2016.4823
MLA
Kasahara, M., Nagahara, M., Nakagawa, T., Ishikawa, T., Sato, T., Uetake, H., Sugihara, K."Clinicopathological relevance of kinesin family member 18A expression in invasive breast cancer". Oncology Letters 12.3 (2016): 1909-1914.
Chicago
Kasahara, M., Nagahara, M., Nakagawa, T., Ishikawa, T., Sato, T., Uetake, H., Sugihara, K."Clinicopathological relevance of kinesin family member 18A expression in invasive breast cancer". Oncology Letters 12, no. 3 (2016): 1909-1914. https://doi.org/10.3892/ol.2016.4823