Familial adenomatous polyposis in China (Review)
- Authors:
- Jun Yang
- Qing Wei Liu
- Liang Wen Li
- Qiang Zhi Wang
- Min Hong
- Jian Dong
-
Affiliations: Department of Oncology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, P.R. China, Department of Internal Medicine‑Oncology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, P.R. China, Department of Internal Medicine‑Oncology, Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650106, P.R. China - Published online on: October 31, 2016 https://doi.org/10.3892/ol.2016.5330
- Pages: 4877-4882
This article is mentioned in:
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|
Gardner EJ, Burt RW and Freston JW: Gastrointestinal polyposis: Syndromes and genetic mechanisms. West J Med. 132:488–499. 1980.PubMed/NCBI | |
|
Bianch KL, Buerke CA, Bennett AE, Lopez R, Hasson H and Church JM: Fundic gland polyp dysplasia is common in familial adenomatous polyposis. Clin Gastroenterol Heptatol. 6:180–185. 2008. View Article : Google Scholar | |
|
Nugent KP and Philips RK: Rectal cancer risk in older patients with familial adenomatous polyposis and an ileorectal anastomosis: A cause for concern. Brit J Surg. 79:1204–1206. 1992. View Article : Google Scholar : PubMed/NCBI | |
|
Jie He and Wan-Qing Chen: Chinese cancer registry annual report. 56–59. 2012. | |
|
Shu Z, Yanqin H and Ying Y: Hereditary colorectal cancer in China. Hered Cancer Clin Pract. 3:155–164. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Yang L, Parkin DM, Li LD, Chen YD and Bray F: Estimation and projection of the national profile of cancer mortality in China: 1991–2005. Br J Cancer. 90:2157–2166. 2004.PubMed/NCBI | |
|
Zhang YZ, Sheng JQ, Li SR and Zhang H: Clinical phenotype and prevalence of hereditary nonpolyposis colorectal cancer syndrome in Chinese population. World J Gastroenterol. 11:1481–1488. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
National Hereditary Colorectal Cancer Network, . Screening program of Chinese hereditary colorectal cancer. Zhonghua Zhong Liu Za Zhi. 26:191–192. 2004.(In Chinese). | |
|
Yutang G, Lu S and Yongbin X: Cancer incidence trend in Shanghai 1972–1994. Tumor. 19:2551999.(In Chinese). | |
|
Jiao Y, Gong E, Meng G, Liu S, Wen E and Ding Y: Detection of APC gene germline mutations in familial adenomatous polyposis patients. Beijing Yi Ke Da Xue Xue Bao. 28:267–269. 1997.(In Chinese). | |
|
Vasen HF: Clinical diagnosis and management of hereditary colorectal cancer syndromes. J Clin Oncol. 18:(21 Suppl). 81S–92S. 2000.PubMed/NCBI | |
|
Romania A, Zakov ZN, McGannon E, Schroeder T, Heyen F and Jagelman DG: Congenital hypertrophy of the retinal pigment epithelium in familial adenomatous polyposis. Ophthalmology. 96:879–984. 1989. View Article : Google Scholar : PubMed/NCBI | |
|
Groden J, Thliveris A, Samowitz W, Carlson M, Gelbert L, Albertsen H, Joslyn G, Stevens J, Spirio L, Robertson M, et al: Identification and characterization of the familial adenomatous polyposis coli gene. Cell. 66:589–600. 1991. View Article : Google Scholar : PubMed/NCBI | |
|
Kinzler KW, Nilbert MC, Vogelstein B, Bryan TM, Levy DB, Smith KJ, Preisinger AC, Hamilton SR, Hedge P, Markham A, et al: Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. Science. 251:1366–1370. 1991. View Article : Google Scholar : PubMed/NCBI | |
|
Ruhswurm I, Zehetmayer M, Dejaco C, Wolf B and Karner-Hanusch J: Ophthalmic and genetic screening in pedigrees with familial adenomatous polyposis. Am J Ophthalmol. 125:680–686. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Half E, Bercovich D and Rozen P: Familial adenomatous polyposis. Orphanet J Rare Dis. 4:222009. View Article : Google Scholar : PubMed/NCBI | |
|
Powell SM, Petersen GM, Krush AJ, Booker S, Jen J, Giardiello FM, Hamilton SR, Vogelstein B and Kinzler KW: Molecular diagnosis of familial adenomatous polyposis. N Engl J Med. 329:1982–1987. 1993. View Article : Google Scholar : PubMed/NCBI | |
|
Sieber OM, Lipton L, Crabtree M, Heinimann K, Fidalgo P, Phillips RK, Bisgaard ML, Orntoft TF, Aaltonen LA, Hodgson SV, et al: Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH. N Eng J Med. 348:791–799. 2003. View Article : Google Scholar | |
|
Quadri M, Vetro A, Gismondi V, Marabelli M, Bertario L, Sala P, Varesco L, Zuffardi O and Ranzani GN: APC rearrangements in familial adenomatous polyposis: Heterogeneity of deletion lengths and breakpoint sequences underlies similar phenotypes. Fam Cancer. 14:41–49. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Ramsoekh D, van Leerdam ME, Tops CM, Dooijes D, Steyerberg EW, Kuipers EJ and Wagner A: The use of genetic testing in hereditary colorectal cancer syndromes: Genetic testing in HNPCC, (A)FAP and MAP. Clin Genet. 72:562–567. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Poulsen ML and Bisgaard ML: MUTYH associated polyposis (MAP). Curr Genomics. 9:420–435. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Venesio T, Balsamo A, D'Agostino VG and Ranzani GN: MUTYH-associated polyposis (MAP), the syndrome implicating base excision repair in inherited predisposition to colorectal tumors. Front Oncol. 2:832012. View Article : Google Scholar : PubMed/NCBI | |
|
Sampson JR, Dolwani S, Jones S, Eccles D, Ellis A, Evans DG, Frayling I, Jordan S, Maher ER, Mak T, et al: Autosomal recessive colorectal adenomatous polyposis due to inherited mutations of MYH. Lancet. 362:39–41. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Kennedy RD, Potter DD, Moir CR and El-Youssef M: The natural history of familial adenomatous polyposis syndrome: A 24 year review of a single center experience in screening, diagnosis, and outcomes. J Pediatr Surg. 49:82–86. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Kennelly RP, Gryfe R and Winter DC: Familial colorectal cancer: Patient assessment, surveillance and surgical management. Eur J Surg Oncol. pii:S0748-S7983.30675-30678. 2016. | |
|
Torrezan GT, da Silva FC, Santos EM, Krepischi AC, Achatz MI, Aguiar S Jr, Rossi BM and Carraro DM: Mutational spectrum of the APC and MUTYH genes and genotype-phenotype correlations in Brazilian FAP, AFAP, and MAP patients. Orphanet J Rare Dis. 8:542013. View Article : Google Scholar : PubMed/NCBI | |
|
Vandrovcová J, Stekrová J, Kebrdlová V and Kohoutová M: Molecular analysis of the APC and MYH genes in Czech families affected by FAP or multiple adenomas: 13 novel mutations. Hum Mutat. 23:3972004. View Article : Google Scholar | |
|
Gómez-Fernández N, Castellví-Bel S, Fernández-Rozadilla C, Balaguer F, Muñoz J, Madrigal I, Milà M, Graña B, Vega A, Castells A, et al: Molecular analysis of the APC and MUTYH genes in Galician and Catalonian FAP families: A different spectrum of mutations? BMC Med Genet. 10:572009. View Article : Google Scholar : PubMed/NCBI | |
|
Rivera B, Gonzalez S, Sánchez-Tomé E, Blanco I, Mercadillo F, Letón R, Benítez J, Robledo M, Capellá G and Urioste M: Clinical and genetic characterization of classical forms of familial adenomatous polyposis: A Spanish population study. Ann Oncol. 22:903–909. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Fostira F, Thodi G, Sandaltzopoulos R, Fountzilas G and Yannoukakos D: Mutational spectrum of APC and genotype-phenotype correlations in Greek FAP patients. BMC Cancer. 10:3892010. View Article : Google Scholar : PubMed/NCBI | |
|
Kanter-Smoler G, Fritzell K, Rohlin A, Engwall Y, Hallberg B, Bergman A, Meuller J, Grönberg H, Karlsson P, Björk J and Nordling M: Clinical characterization and the mutation spectrum in Swedish adenomatous polyposis families. BMC Med. 6:1–10. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Friedl W and Aretz S: Familial adenomatous polyposis: Experience from a study of 1164 unrelated German polyposis patients. Hered Cancer Clin Pract. 3:95–114. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Wachsmannova-Matelova L, Stevurkova V, Adamcikova Z, Holec V and Zajac V: Polymorphisms in the adenomatous polyposis coli gene in Slovak families suspected of FAP. Neuro Endocrinol Lett. 30:(Suppl 1). S25–S28. 2009. | |
|
Liang J, Lin C, Hu F, Wang F, Zhu L, Yao X, Wang Y and Zhao Y: APC polymorphisms and the risk of colorectal neoplasia: A HuGE review and meta-analysis. Am J Epidemiol. 177:1169–1179. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Cai Q, Sun M, Lu H, Zhang T, Mo S, Xu Y, Cai S, Zhu X and Shi D: Clinicopathological and molecular genetic analysis in Chinese typical hereditary nonpolyposis colorectal cancer pedigrees. Zhonghua Bing Li Xue Za Zhi. 30:339–344. 2001.(In Chinese). PubMed/NCBI | |
|
Sheng JQ, Cui WJ, Fu L, Jin P, Han Y, Li SJ, Fan RY, Li AQ, Zhang MZ and Li SR: APC gene mutations in Chinese familial adenomatous polyposis patients. World J Gastroenterol. 16:1522–1526. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Pan M, Cong P, Wang Y, Lin C, Yuan Y, Dong J, Banerjee S, Zhang T, Chen Y, Zhang T, et al: Novel LOVD databases for hereditary breast cancer and colorectal cancer genes in the Chinese population. Hum Mutat. 32:1335–1340. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Su F, Wang T, Zhang MF and Wang BM: The significance of APC protein expression in the Dagnosis of AFAP. Digestive Disease and Endoscopy. 2:26–30. 2008.(In Chinese). | |
|
Su F, Wang T and Wang BM: Attenuated familial adenomatous. Zhong Guo Xiao Hua Nei Jing. 2:20–26. 2008.(In Chinese). | |
|
Lou Z, Yu ED and Meng RG: Attenuated familial adenomatous polyposis. Zhong Hua Wei Chang Wai Ke Za Zhi Bian Ji Bu. 9:81–83. 2006.(In Chinese). | |
|
Yang J, Liu WQ, Li WL, Chen C, Zhu Z, Wang ZQ and Dong J: Detection of APC, MYH and AXIN2 mutations for screening germline mutations predisposing to familial adenomatous polyposis. Shijie Huaren Xiaohua Zazhi. 23:556–562. 2015.(In Chinese). | |
|
Cheng J, Wang B and Wang T: Research progress of MYH-associated polyposis. Guo Ji Xiao Hua Bing Za Zhi She. 30:103–106. 2010.(In Chinese). | |
|
Jing Tong and Bing-Yuan Wang: Relationship between MUTYH gene and occurrence of colorectal cancer in family clan of familial adenomatous polyposis. Shijie Huaren Xiaohua Zazhi. 16:3576–3581. 2008.(In Chinese). | |
|
Zhou HH: Inherited mutations of MUTYH and colorectal cancer. Zhejiang Da Xue Xue Bao Yi Xue Ban. 36:406–411. 2007.(In Chinese). PubMed/NCBI | |
|
Griffioen G, Bus PJ, Vasen HF, Verspaget HW and Lamers CB: Extracolonic manifestations of familial adenomatous polyposis: Desmoid tumours, and upper gastrointestinal adenomas and carcinomas. Scand J Gastroenterol Suppl. 225:85–91. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Konsker KA: Familial adenomatous polyposis: Case report and review of extracolonic manifestations. Mt Sinai J Med. 59:85–91. 1992.PubMed/NCBI | |
|
Bin Zhang: A case of samilial adenomatous polyposis with fundic gland polyps. Clinical Misdiagnosis & Mistherapy. 21:542008.(In Chinese). | |
|
Yan ML, Pan JY, Bai YN, Lai ZD, Chen Z and Wang YD: Adenomas of the common bile duct in familial adenomatous polyposis. World J Gastroenterol. 21:3150–3153. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Hai-Zeng, Dong Shu-Xiao, Zhou Zhi-Xiang and Shao Yong-FU: Familial adenomatous polyposis related Desmoid tumors. The Practical Journal of Cancer. 21:189–194. 2006.(In Chinese). | |
|
Yu ED, Lou Z, Xu XD, Meng RG, Wang H, Jin GX and Fu CG: Diagnosis and therapy of familial adenomatous polyposis with desmoid tumour. Zhong Hua Pu Tong Wai Ke Za Zhi Bian Ji Bu. 21:179–181. 2006.(In Chinese). | |
|
Cao HL, Wang BM and Cao XC: Clinical features of Gardner syndrome and Turcot syndrome in Chinese population: An analysis of 93 cases. Shijie Huaren Xiaohua Zazhi. 18:3922–3925. 2010.(In Chinese). | |
|
Nusliha A, Dalpatadu U, Amarasinghe B, Chandrasinghe PC and Deen KI: Congenital hypertrophy of retinal pigment epithelium (CHRPE) in patients with familial adenomatous polyposis (FAP); a polyposis registry experience. BMC Res Notes. 7:7342014. View Article : Google Scholar : PubMed/NCBI | |
|
Run Chun Li, Jin Wang and Jian Lin: Screening value of congenital hypertrophy of the retinal pigment epithelium for familial adenomatous polyposis. Chinese Journal of Ocular Fundus Diseases. 11:1–3. 1995.(In Chinese). | |
|
Yan Ding, Yu Xu and Xiao-Dong Xu: Research on the fundus fluorescein angiography in congenitaI hypertrophy of the retinaI pigment epithelium in patients with familiaI adenomatous polyposis. International Journal of Ophthalmology. 10:1157–1159. 2010. | |
|
Friedl W, Caspari R, Sengteller M, Uhlhaas S, Lamberti C, Jungck M, Kadmon M, Wolf M, Fahnenstich J, Gebert J, et al: Can APC mutation analysis contribute to therapeutic decisions in familial adenomatous polyposis? Experience from 680 FAP families. Gut. 48:515–521. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Bertario L, Russo A, Sala P, Varesco L, Giarola M, Mondini P, Pierotti M, Spinelli P and Radice P: Hereditary Colorectal Tumor Registry: Multiple approach to the exploration of genotype-phenotype correlations in familial adenomatous polyposis. J Clin Oncol. 21:1698–1707. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Béroud C and Soussi T: APC gene: Database of germline and somatic mutations in human tumors and cell lines. Nucleic Acids Res. 24:121–124. 1996. View Article : Google Scholar : PubMed/NCBI | |
|
Cai SR, Zhang SZ and Zheng S: Detection of adenomatous polyposis coli gene mutations in 31 familial adenomatous polyposis families by using denaturing high performance liquid chromatography. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 25:164–167. 2008.(In Chinese). PubMed/NCBI | |
|
Chen J, Guo L, Peiffer DA, Zhou L, Chan OT, Bibikova M, Wickham-Garcia E, Lu SH, Zhan Q, Wang-Rodriguez J, et al: Genomic profiling of 766 cancer-related genes in archived esophageal normal and carcinoma tissues. Int J Cancer. 122:2249–2254. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Gismondi V, Meta M, Bonelli L, Radice P, Sala P, Bertario L, Viel A, Fornasarig M, Arrigoni A, Gentile M, et al: Prevalence of the Y165C, G382D and 1395delGGA germline mutations of the MYH gene in Italian patients with adenomatous polyposis coli and colorectal adenomas. Int J Cancer. 109:680–684. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Ashton KA, Meldrum CJ, McPhillips ML, Kairupan CF and Scott RJ: Frequency of the Common MYH Mutations (G382D and Y165C) in MMR Mutation Positive and Negative HNPCC Patients. Hered Cancer Clin Pract. 3:65–70. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Castellsagué E, González S, Guinó E, Stevens KN, Borràs E, Raymond VM, Lázaro C, Blanco I, Gruber SB and Capellá G: Allele-specific expression of APC in adenomatous polyposis families. Gastroenterology. 139:439–447.e1. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Renkonen ET, Nieminen P, Abdel-Rahman WM, Moisio AL, Järvelä I, Arte S, Järvinen HJ and Peltomäki P: Adenomatous polyposis families that screen APC mutation-negative by conventional methods are genetically heterogeneous. J Clin Oncol. 23:5651–5659. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Warrier SK and Kalady MF: Familial adenomatous polyposis: Challenges and pitfalls of surgical treatment. Clin Colon Rectal Surg. 25:83–89. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Leonard D, Wolthuis A, D'Hoore A, Bruyninx L, Van De Stadt J, Van Cutsem E and Kartheuser A: Different surgical strategies in the treatment of familial adenomatous polyposis: What's the role of the ileal pouch-anal anastomosis? Acta Gastroenterol Belg. 74:427–434. 2011.PubMed/NCBI | |
|
XIE Yu-Quan, Yuan Xing-Hua, Zheng Zhao-XU and Fang YI: Meta analysis of surgical treatment of 231 cases of familial adenomatous polyposis in China. Chinese Journal of Cancer Prevention and Treatment. 15:537–540. 2008.(In Chinese). | |
|
Wen Y, Lu J, Zhu M, Wu Ch, Li L and Zhu W: Surgical treatment of familial adenomatous polyposis: A report of 45 cases. Zhong Hua Pu Tong Wai Ke Za Zhi Bian Ji Bu. 13:673–675. 2004.(In Chinese). | |
|
Zhen Si-Hu, Hou Hui-Chi, Wang Shao-Wen, LI Wei and Liu Wei: Laparoscopic total colectomy for familial adenomatous polyposis with a report of 9 cases. Journal of Regional Anatomy and Operative Surgery. 22:629–630. 2013.(In Chinese). | |
|
Moussata D, Napoleon B, Lepilliez V, Klich A, Ecochard R, Lapalus MG, Nancey S, Cenni JC, Ponchon T, Chayvialle JA and Saurin JC: Endoscopic treatment of severe duodenal polyposis as an alternative to surgery for patients with familial adenomatous polyposis. Gastrointest Endosc. 80:817–825. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Nie Y, Zhang R, Fan K and Liang H: Familial adenomatous polyposis: A report of 10 cases in 3 generations of a family and literature review. Zhonghua Nei Ke Za Zhi. 53:290–292. 2014.(In Chinese). PubMed/NCBI | |
|
He JT, Li XL, Jiang XY, Li J, Gong LS, Zhang YD and Lu Jand Liao CX: Clinical study on familial adenomatous polyposis treated by high frequency electric cutting under endoscope. China Journal of Modern Medicine. 16:568–570. 2006.(In Chinese). | |
|
Cooper K, Squires H, Carroll C, Papaioannou D, Booth A, Logan RF, Maguire C, Hind D and Tappenden P: Chemoprevention of colorectal cancer: Systematic review and economic evaluation. Health Technol Assess. 14:1–206. 2010. View Article : Google Scholar | |
|
Lang M and Gasche C: Chemoprevention of colorectal cancer. Dig Dis. 33:58–67. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Waddell WR and Loughry RW: Sulindac for polyposis of the colon. J Surg Oncol. 24:83–87. 1983. View Article : Google Scholar : PubMed/NCBI | |
|
Li J, Lu Y, Gu F, An Y and Qian Y: The long-term effects of sulindac on familial adenomatous polyposis. Zhong Hua Ziao Hua Za Zhi Bian Ji Bu. 25:153–156. 2005.(In Chinese). | |
|
Huang K, Gutierrez LP, Bülow S, Gallinger S, Castells A, Eagle CJ and Church JM: Clinical characteristics and outcomes in familial adenomatous polyposis patients with a long-term treatment of celecoxib: A matched cohort study. Fam Cancer. 10:303–308. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Wang J and Luo M: Treatment of upper gastrointestinal polyps in familial adenomatous polyposis with celexib. Chin J Surg. 43:1962003.(In Chinese). | |
|
Schnitzer TJ, Burmester GR, Mysler E, Hochberg MC, Doherty M, Ehrsam E, Gitton X, Krammer G, Mellein B, Matchaba P, et al: Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), reduction in ulcer complications: Randomised controlled trial. Lancet. 364:665–674. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Lynch PM, Ayers GD, Hawk E, Richmond E, Eagle C, Woloj M, Church J, Hasson H, Patterson S, Half E and Burke CA: The safety and efficacy of celecoxib in children with familial adenomatous polyposis. Am J Gastroenterol. 105:1437–1443. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Lynch PM, Burke CA, Phillips R, Morris JS, Slack R, Wang X, Liu J, Patterson S, Sinicrope FA, Rodriguez-Bigas MA, et al: An international randomised trial of celecoxib versus celecoxib plus difluoromethylornithine in patients with familial adenomatous polyposis. Gut. 65:286–295. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Cao Yong and Zheng Chang-Qing: Effects of celecoxib combined with high frequency electric cutting under endoscopy on familial adenomatous polyposis. Practical Pharmacy And Clinical Remedies. 14:209–211. 2011.(In Chinese). | |
|
Li SB, Tong Q, Gao YJ, Wang Q, Zhang WG and Wang XH: A clinical study of celecoxib plus RFA/high frequency electrocoagulation and electrocision in treatment of familial adenomatous polyposis. Wei Chang Bing Xue Bian Ji Bu. 14:615–617. 2009.(In Chinese). | |
|
An A-Yue, Zheng Li-Hua and Huang Yue: Treatment of 15 FAP patients by oral administration and retention enema of TCM. Zhong Ji Yi Kan. 30:44–45. 1995.(In Chinese). | |
|
Huo Qing-Ping and Kong Lin: Treatment experience of a familial adenomatous polyposis case. SH J TCM. 42:12–13. 2008.(In Chinese). | |
|
Jiao Kai-Shan: Analysis of spatial statistics about Chinese minority population distribution and its changes. Journal of Southwest University for Nationalities (Humanities and Social Science). 10:26–32. 2014.(In Chinese). | |
|
Piao M, Cao H, He N, Yang B, Dong W, Xu M, Yan F, Zhou B and Wang B: Berberine inhibits intestinal polyps growth in Apc (min/+) mice via regulation of macrophage polarization. Evid Based Complement Alternat Med. 2016:51375052016. View Article : Google Scholar : PubMed/NCBI | |
|
Xu J and Yang Y: Traditional Chinese medicine in the Chinese health care system. Health Policy. 90:133–139. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Ping B: The effects of Chinese drugs for supporting healthy energy and removing blood stasis on postoperative metastasis of gastric carcinoma and ornithine decarboxylase. J Tradit Chin Med. 18:3–6. 1998.PubMed/NCBI |
