Expression of survivin, MUC2 and MUC5 in colorectal cancer and their association with clinicopathological characteristics

  • Authors:
    • Haipeng Wang
    • Shengjian Jin
    • Huiling Lu
    • Sisi Mi
    • Wenhua Shao
    • Xiaoxv Zuo
    • Huangyi Yin
    • Sien Zeng
    • Fumio Shimamoto
    • Guangying Qi
  • View Affiliations

  • Published online on: May 19, 2017     https://doi.org/10.3892/ol.2017.6218
  • Pages: 1011-1016
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Survivin is a bifunctional protein that suppresses apoptosis and regulates cell division, and is highly expressed in various cancer types. Mucins are high‑molecular‑weight, heavily glycosylated proteins. In the present study, the association between survivin, mucin 2 (MUC2) and MUC5 expression, and the clinicopathological features of colorectal cancer (CRC) were investigated. The immunohistochemistry and western blotting results demonstrated that survivin was highly expressed in CRC tissues and rarely expressed in normal colon tissues. Moreover, the overexpression of survivin and MUC5 was strongly associated with lymph node metastasis, poor cellular differentiation, advanced tumor stage and a poor prognosis in CRC. By contrast, low expression of MUC2 was significantly associated with lymph node metastasis, poor cellular differentiation and an advanced tumor stage in CRC. The results of the present study suggest that survivin, MUC2 and MUC5 levels may be associated with tumor progression and could be used to aid the early diagnosis and clinical characterization of CRC.
View Figures
View References

Related Articles

Journal Cover

July-2017
Volume 14 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Wang H, Jin S, Lu H, Mi S, Shao W, Zuo X, Yin H, Zeng S, Shimamoto F, Qi G, Qi G, et al: Expression of survivin, MUC2 and MUC5 in colorectal cancer and their association with clinicopathological characteristics. Oncol Lett 14: 1011-1016, 2017
APA
Wang, H., Jin, S., Lu, H., Mi, S., Shao, W., Zuo, X. ... Qi, G. (2017). Expression of survivin, MUC2 and MUC5 in colorectal cancer and their association with clinicopathological characteristics. Oncology Letters, 14, 1011-1016. https://doi.org/10.3892/ol.2017.6218
MLA
Wang, H., Jin, S., Lu, H., Mi, S., Shao, W., Zuo, X., Yin, H., Zeng, S., Shimamoto, F., Qi, G."Expression of survivin, MUC2 and MUC5 in colorectal cancer and their association with clinicopathological characteristics". Oncology Letters 14.1 (2017): 1011-1016.
Chicago
Wang, H., Jin, S., Lu, H., Mi, S., Shao, W., Zuo, X., Yin, H., Zeng, S., Shimamoto, F., Qi, G."Expression of survivin, MUC2 and MUC5 in colorectal cancer and their association with clinicopathological characteristics". Oncology Letters 14, no. 1 (2017): 1011-1016. https://doi.org/10.3892/ol.2017.6218