Antitumor effects of curcumin in human bladder cancer in vitro

  • Authors:
    • Jing Shi
    • Xu Zhang
    • Taoping Shi
    • Hongzhao Li
  • View Affiliations

  • Published online on: May 18, 2017     https://doi.org/10.3892/ol.2017.6205
  • Pages: 1157-1161
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Bladder cancer is one of the major causes of cancer‑associated mortality, with a high incidence. Curcumin, a polyphenol compound extracted from turmeric, has been identified to regulate tumor progression. However, the therapeutic effect of curcumin in human bladder cancer has not yet been determined. In the present study, the effects of curcumin on cell growth, apoptosis and migration of bladder cancer cell lines were evaluated using an MTT assay, a Transwell assay and flow cytometry, and the associated mechanisms were investigated using western blot analysis. Curcumin was identified to decrease the growth of T24 and 5637 cells in a dose‑ and time‑dependent manner. The present study confirmed that curcumin is able to inhibit cell migration and promote apoptosis of bladder cancer through suppression of matrix metalloproteinase signaling pathways in vitro. The anticancer effects of curcumin on bladder cancer cells may benefit clinical practice in the future.
View Figures
View References

Related Articles

Journal Cover

July-2017
Volume 14 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Shi J, Zhang X, Shi T and Li H: Antitumor effects of curcumin in human bladder cancer in vitro. Oncol Lett 14: 1157-1161, 2017
APA
Shi, J., Zhang, X., Shi, T., & Li, H. (2017). Antitumor effects of curcumin in human bladder cancer in vitro. Oncology Letters, 14, 1157-1161. https://doi.org/10.3892/ol.2017.6205
MLA
Shi, J., Zhang, X., Shi, T., Li, H."Antitumor effects of curcumin in human bladder cancer in vitro". Oncology Letters 14.1 (2017): 1157-1161.
Chicago
Shi, J., Zhang, X., Shi, T., Li, H."Antitumor effects of curcumin in human bladder cancer in vitro". Oncology Letters 14, no. 1 (2017): 1157-1161. https://doi.org/10.3892/ol.2017.6205