Expression of FOXC2, PinX1, Ki-67 and Cyclin D1 in cutaneous cell carcinoma

Zhao,Haiying; Cao,Yunfeng; Wang,Guoqiang; Luo,Zengxiang

doi:10.3892/ol.2017.6244

Expression of FOXC2, PinX1, Ki-67 and Cyclin D1 in cutaneous cell carcinoma

Authors:
- Haiying Zhao
- Yunfeng Cao
- Guoqiang Wang
- Zengxiang Luo
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Affiliations: Department of Dermatology and Sexually Transmitted Disease, Binzhou City Center Hospital, Binzhou, Shandong 251700, P.R. China, Department of Oncology, Binzhou City Center Hospital, Binzhou, Shandong 251700, P.R. China, Department of Dermatology, Affiliated Hospital of Weifang Medical University, Weifang, Shandong 261031, P.R. China
Published online on: May 24, 2017 https://doi.org/10.3892/ol.2017.6244
Pages: 635-638
Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

We investigated the expression of FOXC2, PinX1, Ki-67 and Cyclin D1 in cutaneous cell carcinoma. We collected 30 cutaneous squamous cell carcinoma (SCC), 30 cutaneous basal cell carcinoma (BCC) and 30 normal skin tissues. The protein expression and gene expression of FOXC2, endogenous telomerase-inhibiting gene PinX1, Ki-67 and Cyclin D1 was measured by immunohistochemistry (IHC) and semi-quantitative reverse transcription polymerase chain reaction (RT-PCR), respectively. In SCC and BCC tissues, the positive rate of protein expression and mRNA level of PinX1 were both significantly lower than those in normal tissues. However, the positive rate of protein expression and mRNA level of FOXC2, Ki-67 and Cyclin D1 were significantly higher than those in normal tissues (p<0.05). There was no significant difference between SCC and BCC (p>0.05). In conclusion, FOXC2 may participate in the carcinogenesis process of SCC and BCC. It may also correlate with the expression PinX, Ki-67 and Cyclin D1. However, FOXC2 alone cannot be used as a diagnostic indicator of SCC.

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