Open Access

Silencing of semaphorin 3C suppresses cell proliferation and migration in MCF‑7 breast cancer cells

  • Authors:
    • Xiaofang Zhu
    • Xiangjian Zhang
    • Zhiqiang Ye
    • Yizuo Chen
    • Lin Lv
    • Xiaohua Zhang
    • Hongye Hu
  • View Affiliations

  • Published online on: September 8, 2017     https://doi.org/10.3892/ol.2017.6920
  • Pages: 5913-5917
  • Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Previous studies have suggested that semaphorin 3C (SEMA3C) is involved in the tumorigenesis and metastasis of a number of types of cancer. The aim of the present study was to investigate the role of SEMA3C in the proliferation and migration of MCF‑7 breast cancer cells. Small interfering (si)RNA sequences targeting SEMA3C were constructed and transfected into MCF‑7 cells in order to silence the expression of SEMA3C. Cell proliferation and migration were measured using CCK‑8 and Transwell assays, respectively. Transfection with SEMA3C siRNA significantly downregulated the expression of SEMA3C in MCF‑7 cells, and significantly suppressed cell proliferation and migration. Therefore, SEMA3C‑targeted siRNA may be of potential use for the early diagnosis and treatment of breast cancer.
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November-2017
Volume 14 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Zhu X, Zhang X, Ye Z, Chen Y, Lv L, Zhang X and Hu H: Silencing of semaphorin 3C suppresses cell proliferation and migration in MCF‑7 breast cancer cells. Oncol Lett 14: 5913-5917, 2017
APA
Zhu, X., Zhang, X., Ye, Z., Chen, Y., Lv, L., Zhang, X., & Hu, H. (2017). Silencing of semaphorin 3C suppresses cell proliferation and migration in MCF‑7 breast cancer cells. Oncology Letters, 14, 5913-5917. https://doi.org/10.3892/ol.2017.6920
MLA
Zhu, X., Zhang, X., Ye, Z., Chen, Y., Lv, L., Zhang, X., Hu, H."Silencing of semaphorin 3C suppresses cell proliferation and migration in MCF‑7 breast cancer cells". Oncology Letters 14.5 (2017): 5913-5917.
Chicago
Zhu, X., Zhang, X., Ye, Z., Chen, Y., Lv, L., Zhang, X., Hu, H."Silencing of semaphorin 3C suppresses cell proliferation and migration in MCF‑7 breast cancer cells". Oncology Letters 14, no. 5 (2017): 5913-5917. https://doi.org/10.3892/ol.2017.6920