Herbal compound Teng‑Long‑Bu‑Zhong‑Tang inhibits metastasis in human RKO colon carcinoma

Wei,Meng‑Meng; Wang,Shuang‑Shuang; Zheng,Jia‑Lu; Chen,Jin‑Jun; Yan,Xia; An,Hong‑Mei; Hu,Bing

doi:10.3892/ol.2017.7206

Herbal compound Teng‑Long‑Bu‑Zhong‑Tang inhibits metastasis in human RKO colon carcinoma

Authors:
- Meng‑Meng Wei
- Shuang‑Shuang Wang
- Jia‑Lu Zheng
- Jin‑Jun Chen
- Xia Yan
- Hong‑Mei An
- Bing Hu
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Affiliations: Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, P.R. China, Department of Plastic and Reconstructive Surgery, Shanghai Key Laboratory of Tissue Engineering, The Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200011, P.R. China, Department of Science and Technology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, P.R. China
Published online on: October 18, 2017 https://doi.org/10.3892/ol.2017.7206
Pages: 7767-7772
Copyright: © Wei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Metastasis is one of the primary obstacles to the successful treatment of colorectal cancer. Teng‑Long‑Bu‑ Zhong‑Tang (TLBZT) is a modern Chinese herbal formula that may be useful in the treatment of metastatic colorectal cancer. The present study evaluated the effects of TLBZT on lung metastasis in human RKO colon carcinoma cells injected into mice via the tail vein. The results demonstrated that TLBZT inhibited the metastasis of human RKO colon carcinoma cells to the lungs. TLBZT downregulated the expression of LOX and hypoxia‑inducible factor 1α. TLBZT also inhibited the expression of integrins αV and β3 and the phosphorylation of focal adhesion kinase. These results indicate that TLBZT inhibits the lung metastasis of RKO colon carcinoma by regulating the expression of multiple genes. The results of the present study provide a new basis for the management of colorectal cancer metastasis using treatments derived from Chinese herbs.

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