Function of insulin‑like growth factor 1 receptor in cancer resistance to chemotherapy (Review)

  • Authors:
    • Jingsheng Yuan
    • Zhijie Yin
    • Kaixiong Tao
    • Guobing Wang
    • Jinbo Gao
  • View Affiliations

  • Published online on: October 26, 2017     https://doi.org/10.3892/ol.2017.7276
  • Pages:41-47
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Abstract

Drug resistance is a primary cause of chemo­therapeutic failure; however, how this resistance develops is complex. A comprehensive understanding of chemotherapeutic resistance mechanisms may aid in identifying more effective drugs and improve the survival rates of patients with cancer. Insulin‑like growth factor 1 receptor (IGF1R), a member of the insulin receptor family, has been extensively assessed for biological activity, and its putative contribution to tumor cell development and progression. Furthermore, researchers have attended to drugs that target IGF1R since IGF1R functions as a membrane receptor. However, how IGF1R participates in chemotherapeutic resistance remains unclear. Therefore, the present study described the IGF1R gene and its associated signaling pathways, and offered details of IGF1R‑induced tumor chemoresistance associated with promoting cell proliferation, inhibition of apoptosis, regulation of ATP‑binding cassette transporter proteins and interactions with the extracellular matrix. The present study offered additional explanations for tumor chemotherapy resistance and provided a theoretical basis of IGF1R and its downstream pathways for future possible chemotherapy treatment options.

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January 2018
Volume 15 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Yuan, J., Yin, Z., Tao, K., Wang, G., & Gao, J. (2018). Function of insulin‑like growth factor 1 receptor in cancer resistance to chemotherapy (Review). Oncology Letters, 15, 41-47. https://doi.org/10.3892/ol.2017.7276
MLA
Yuan, J., Yin, Z., Tao, K., Wang, G., Gao, J."Function of insulin‑like growth factor 1 receptor in cancer resistance to chemotherapy (Review)". Oncology Letters 15.1 (2018): 41-47.
Chicago
Yuan, J., Yin, Z., Tao, K., Wang, G., Gao, J."Function of insulin‑like growth factor 1 receptor in cancer resistance to chemotherapy (Review)". Oncology Letters 15, no. 1 (2018): 41-47. https://doi.org/10.3892/ol.2017.7276