Mitogen-activated protein kinase signaling pathway in oral cancer (Review)

  • Authors:
    • Qian Peng
    • Zhiyuan Deng
    • Hao Pan
    • Liqun Gu
    • Ousheng Liu
    • Zhangui Tang
  • View Affiliations

  • Published online on: November 24, 2017     https://doi.org/10.3892/ol.2017.7491
  • Pages:1379-1388
Metrics: HTML 0 views | PDF 0 views     Cited By (CrossRef): 0 citations

Abstract

The mitogen-activated protein kinase (MAPK) signaling pathway is associated with tumor cell proliferation, differentiation, apoptosis, angiogenesis, invasion and metastasis. The present review assesses the involvement of the MAPK signaling pathway in oral cancer progression and invasion based on analysis of individual sub‑pathways and their mechanisms of action. The regulation of this pathway for targeted oral cancer therapy is explored and the challenges confronting this, as well as corresponding potential solutions, are discussed. Exploring this pathway with an emphasis on its components, subfamilies, sub‑pathways, interactions with other pathways and clinical practice modes may improve oral cancer treatment.

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February 2018
Volume 15 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
(total number of cites)

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APA
Peng, Q., Deng, Z., Pan, H., Gu, L., Liu, O., & Tang, Z. (2018). Mitogen-activated protein kinase signaling pathway in oral cancer (Review). Oncology Letters, 15, 1379-1388. https://doi.org/10.3892/ol.2017.7491
MLA
Peng, Q., Deng, Z., Pan, H., Gu, L., Liu, O., Tang, Z."Mitogen-activated protein kinase signaling pathway in oral cancer (Review)". Oncology Letters 15.2 (2018): 1379-1388.
Chicago
Peng, Q., Deng, Z., Pan, H., Gu, L., Liu, O., Tang, Z."Mitogen-activated protein kinase signaling pathway in oral cancer (Review)". Oncology Letters 15, no. 2 (2018): 1379-1388. https://doi.org/10.3892/ol.2017.7491