Increased expression of mitochondrial transcription factor A and nuclear respiratory factor‑1 predicts a poor clinical outcome of breast cancer

Gao,Wei; Wu,Meihong; Wang,Ning; Zhang,Yingyi; Hua,Jing; Tang,Gusheng; Wang,Yajie

doi:10.3892/ol.2017.7487

Increased expression of mitochondrial transcription factor A and nuclear respiratory factor‑1 predicts a poor clinical outcome of breast cancer

Authors:
- Wei Gao
- Meihong Wu
- Ning Wang
- Yingyi Zhang
- Jing Hua
- Gusheng Tang
- Yajie Wang
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Affiliations: Department of Radiation Oncology, Shanghai 9th People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200433, P.R. China, Department of Oncology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, P.R. China, Department of Hematology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, P.R. China
Published online on: November 24, 2017 https://doi.org/10.3892/ol.2017.7487
Pages: 1449-1458
Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Nuclear respiratory factor‑1 (Nrf1) and mitochondrial transcription factor A (TFAM) are involved in the regulation of a variety of mitochondrial functional genes, which are associated with decreased sensitivity of tumor cells to chemotherapy. However, the expression status of Nrf1 and TFAM, as well as their clinical significance in breast cancer, is unknown. In the present study, tumor tissues and corresponding adjacent normal tissues were collected from 336 patients with breast cancer, and Nrf1 and TFAM expression was analyzed by immunohistochemistry using a tissue microarray. Expression of Nrf1 and TFAM was significantly increased in breast cancer tissue compared with adjacent normal tissues. In addition, patients positive for Nrf1 or TFAM had a poorer clinical prognosis than patients who were negative, and those positive for Nrf1 and TFAM had the shortest survival time. These results suggest that Nrf1 and TFAM are potential biomarkers for the determination of individualized therapy and the prognosis of breast cancer, and molecular targeting of Nrf1 and TFAM is a promising strategy for the sensitization of breast cancer cells to chemotherapeutics.

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