Open Access

The relationship between cervical precancerous lesion galectin-3 and p27 protein expression and clinical prognosis

  • Authors:
    • Jianting Ma
    • Xingguang Zhang
    • Gang He
    • Chunlin Yang
  • View Affiliations

  • Published online on: November 29, 2017     https://doi.org/10.3892/ol.2017.7503
  • Pages:1533-1536
  • Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The relationship between galectin-3 and p27kip1 protein expression levels in cervical precancerous lesions and clinical prognosis were studied. A total of 74 patients with cervical intraepithelial neoplasia [(CIN), 20 cases classified as stage I, 24 cases as stage II and 30 cases as stage III] were enrolled in this study. Tissue galectin-3, p27kip1, vascular endothelial growth factor (VEGF)-2 and cyclin D protein levels were detected via immunohistochemical staining and reverse transcription polymerase chain reaction (PCR). Follow-up median duration was 13.5 months and recurrence rate was determined. Galectin-3, VEGF-2, and cyclin D expression was elevated in patients with higher stage CIN, whereas p27kip1 showed the opposite trend (p<0.05). During follow-up, there were 3 cases (15.0%) of recurrence in the CIN-I group, 5 cases (20.8%) in the CIN-II group and 9 cases (30.0%) in CIN-III the group. No significant difference in recurrence rate was noted among the groups (p>0.05). The upregulation of galectin-3 and downregulation of p27kip1 in CIN tissues may be related to tumor progression. This phenomenon will require further verification.

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February 2018
Volume 15 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Ma, J., Zhang, X., He, G., & Yang, C. (2018). The relationship between cervical precancerous lesion galectin-3 and p27 protein expression and clinical prognosis. Oncology Letters, 15, 1533-1536. https://doi.org/10.3892/ol.2017.7503
MLA
Ma, J., Zhang, X., He, G., Yang, C."The relationship between cervical precancerous lesion galectin-3 and p27 protein expression and clinical prognosis". Oncology Letters 15.2 (2018): 1533-1536.
Chicago
Ma, J., Zhang, X., He, G., Yang, C."The relationship between cervical precancerous lesion galectin-3 and p27 protein expression and clinical prognosis". Oncology Letters 15, no. 2 (2018): 1533-1536. https://doi.org/10.3892/ol.2017.7503