PI3K/AKT/Afadin signaling pathway contributes to pathological vascularization in glioblastomas

  • Authors:
    • Xuan Zhai
    • Yingliang Li
    • Ping Liang
    • Lusheng Li
    • Yudong Zhou
    • Weidan Zhang
    • Difei Wang
    • Guanghui Wei
  • View Affiliations

  • Published online on: November 21, 2017     https://doi.org/10.3892/ol.2017.7461
  • Pages:1893-1899
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Abstract

Glioblastomas are brain tumors with extensive vascularization that are associated with tumor malignancy. The phosphoinositide 3‑kinase (PI3K)/protein kinase B (AKT) signaling pathway is activated in endothelial cell tumors, although its exact function in glioblastoma neovascularization is poorly characterized. The present study identified that endothelial cells derived from human glioblastomas exhibit increased permeability and motility compared with normal brain vascular endothelial cells. Furthermore, the phosphorylation of AKT was significantly induced in glioblastoma‑derived endothelial cells and glioblastoma vessels. To the best of our knowledge, the present study demonstrated for the first time that the cell‑cell adhesion junction protein Afadin is phosphorylated and re‑localized in glioblastoma‑derived endothelial cells, and the phosphorylation and re‑localization of Afadin is PI3K/AKT pathway‑dependent. AKT‑mediated phosphorylation and re‑localization of Afadin may be critically involved in the modulation of brain endothelial permeability and migration. Therapies targeting the PI3K/AKT/Afadin pathway may therefore be beneficial for reducing the angiogenic potential of glioblastoma.

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February 2018
Volume 15 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Zhai, X., Li, Y., Liang, P., Li, L., Zhou, Y., Zhang, W. ... Wei, G. (2018). PI3K/AKT/Afadin signaling pathway contributes to pathological vascularization in glioblastomas. Oncology Letters, 15, 1893-1899. https://doi.org/10.3892/ol.2017.7461
MLA
Zhai, X., Li, Y., Liang, P., Li, L., Zhou, Y., Zhang, W., Wang, D., Wei, G."PI3K/AKT/Afadin signaling pathway contributes to pathological vascularization in glioblastomas". Oncology Letters 15.2 (2018): 1893-1899.
Chicago
Zhai, X., Li, Y., Liang, P., Li, L., Zhou, Y., Zhang, W., Wang, D., Wei, G."PI3K/AKT/Afadin signaling pathway contributes to pathological vascularization in glioblastomas". Oncology Letters 15, no. 2 (2018): 1893-1899. https://doi.org/10.3892/ol.2017.7461