Combined small cell carcinoma with giant cell carcinoma component of the lung: A case successfully diagnosed by computed tomography‑guided fine‑needle aspiration cytology

  • Authors:
    • Yusuke Ebisu
    • Mitsuaki Ishida
    • Tomohito Saito
    • Tomohiro Murakawa
    • Yoshiko Uemura
    • Koji Tsuta
  • View Affiliations

  • Published online on: November 20, 2017     https://doi.org/10.3892/ol.2017.7448
  • Pages: 1907-1911
Metrics: HTML 0 views | PDF 0 views     Cited By (CrossRef): 0 citations

Abstract

Combined small cell lung carcinoma (SCLC) is a rare variant of SCLC and is defined as a mixture of SCLC and non‑SCLC components. Although any histopathological subtype may be present as a non‑SCLC component, the presence of pleomorphic carcinoma components are extremely rare. The present report describes the first documented cytological features of combined SCLC with a giant cell carcinoma component. A 50‑year‑old Japanese female with a history of smoking presented with a mass lesion in the left lung. Computed tomography‑guided fine‑needle aspiration cytology and needle biopsy were performed, followed by a lobectomy. A Papanicolaou smear revealed the presence of two distinct neoplastic components in a necrotic background. One component was SCLC, which comprised small‑sized neoplastic cells containing scant cytoplasm and round to oval nuclei with dispersed granular chromatin without nucleoli. The other component was giant cell carcinoma, which was composed of large‑sized neoplastic cells containing irregular large hyperchromatic nuclei (approximately 7 to 10 times larger than those of SCLC). SCLC was demonstrated in the biopsy specimen, however no giant cell carcinoma component was present. Histopathological study of the lobectomy specimen verified a diagnosis of combined SCLC with giant cell carcinoma component. Both SCLC and giant cell carcinoma exhibit characteristic cytological features, therefore, albeit extremely rare, careful observation may lead to a correct diagnosis of combined SCLC in the cytological specimen.

Related Articles

Journal Cover

February 2018
Volume 15 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Ebisu, Y., Ishida, M., Saito, T., Murakawa, T., Uemura, Y., & Tsuta, K. (2018). Combined small cell carcinoma with giant cell carcinoma component of the lung: A case successfully diagnosed by computed tomography‑guided fine‑needle aspiration cytology. Oncology Letters, 15, 1907-1911. https://doi.org/10.3892/ol.2017.7448
MLA
Ebisu, Y., Ishida, M., Saito, T., Murakawa, T., Uemura, Y., Tsuta, K."Combined small cell carcinoma with giant cell carcinoma component of the lung: A case successfully diagnosed by computed tomography‑guided fine‑needle aspiration cytology". Oncology Letters 15.2 (2018): 1907-1911.
Chicago
Ebisu, Y., Ishida, M., Saito, T., Murakawa, T., Uemura, Y., Tsuta, K."Combined small cell carcinoma with giant cell carcinoma component of the lung: A case successfully diagnosed by computed tomography‑guided fine‑needle aspiration cytology". Oncology Letters 15, no. 2 (2018): 1907-1911. https://doi.org/10.3892/ol.2017.7448