Open Access

Long-term outcomes of patients with soft tissue sarcoma of the chest wall: Analysis of the prognostic significance of microscopic margins

  • Authors:
    • Kamran Harati
    • Jonas Kolbenschlag
    • Jens Bohm
    • Hiltrud Niggemann
    • Hamid Joneidi‑Jafari
    • Ingo Stricker
    • Marcus Lehnhardt
    • Adrien Daigeler
  • View Affiliations

  • Published online on: December 14, 2017     https://doi.org/10.3892/ol.2017.7624
  • Pages:2179-2187
  • Copyright: © Harati et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Data on prognostic factors and treatment outcomes for chest wall soft tissue sarcomas (STS) are sparse. Wide resections with negative margins are the mainstay of therapy, but the prognostic impact of surgical margins remains controversial. The purpose of the present study was to determine the significance of microscopic margins through a long‑term follow‑up. The associations between local recurrence‑free survival (LRFS), overall survival (OS) and potential prognostic factors were retrospectively assessed in a consecutive series of 110 patients who were suitable for surgical treatment with curative intent. Potential prognostic factors were assessed using univariate and multivariate analyses. The median follow‑up time following primary diagnosis was 9.6 years [95% confidence interval (CI), 7.2‑10.5]. In the entire cohort, the 5‑year estimates of the OS and LRFS rates were 66.0% (95% CI, 55.9‑74.3) and 60.6% (95% CI, 50.3‑69.4), respectively. A total of 27 patients (24.5%) developed distant metastases with a median survival time of 0.9 years following the diagnosis of metastasis. Surgical margins attained at the initial resection and eventual re‑excisions significantly influenced OS in univariate analysis (5‑year OS, R0 69.9% vs. R1/R2 38.5%; P=0.046), but this failed to reach statistical significance in the multivariate analysis. In the multivariate analysis, significant adverse prognostic features of LRFS included angiosarcoma subtype, G2 and G3 histology. For OS, the only independent significant predictors were age >50 years, tumor size >5 cm, angiosarcoma subtype and G3 histology. The results of the present study suggest that tumor biology, as reflected by the histological grade, influences the final outcome in patients with chest wall STS. Surgical margins failed to reach statistical significance in multivariate analysis as they demonstrated a dependency towards the independent predictors of OS. Subsequently, a positive margin status may be a result rather than a cause of biological aggressiveness, and it may not influence the outcome directly.

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February 2018
Volume 15 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Harati, K., Kolbenschlag, J., Bohm, J., Niggemann, H., Joneidi‑Jafari, H., Stricker, I. ... Daigeler, A. (2018). Long-term outcomes of patients with soft tissue sarcoma of the chest wall: Analysis of the prognostic significance of microscopic margins. Oncology Letters, 15, 2179-2187. https://doi.org/10.3892/ol.2017.7624
MLA
Harati, K., Kolbenschlag, J., Bohm, J., Niggemann, H., Joneidi‑Jafari, H., Stricker, I., Lehnhardt, M., Daigeler, A."Long-term outcomes of patients with soft tissue sarcoma of the chest wall: Analysis of the prognostic significance of microscopic margins". Oncology Letters 15.2 (2018): 2179-2187.
Chicago
Harati, K., Kolbenschlag, J., Bohm, J., Niggemann, H., Joneidi‑Jafari, H., Stricker, I., Lehnhardt, M., Daigeler, A."Long-term outcomes of patients with soft tissue sarcoma of the chest wall: Analysis of the prognostic significance of microscopic margins". Oncology Letters 15, no. 2 (2018): 2179-2187. https://doi.org/10.3892/ol.2017.7624