Open Access

Vernodalol mediates antitumor effects in acute promyelocytic leukemia cells

  • Authors:
    • Wenjun Wu
    • Xiaoyan Han
    • Cai Wu
    • Guoqing Wei
    • Gaofeng Zheng
    • Yi Li
    • Yang Yang
    • Li Yang
    • Donghua He
    • Yi Zhao
    • Zhen Cai
  • View Affiliations

  • Published online on: December 7, 2017     https://doi.org/10.3892/ol.2017.7544
  • Pages:2227-2235
  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Acute promyelocytic leukemia (APL) remains a challenge to cure due to the side effects of cytotoxic chemotherapy and drug resistance. The present study demonstrated that vernodalol, an active compound isolated from Centratherum anthelminticum, suppresses APL cell proliferation and induces cell cycle arrest in the G2/M phase through the upregulation of p21 and cell division cycle 25. In addition, vernodalol induced cellular apoptosis via the mitochondrial pathway as observed by the cleavage of caspase‑9 as well as the release of cytochrome c and Smac/DIABLO into the cytosol. A mechanistic study revealed that vernodalol may exert its antitumor activity through the suppression of phosphoinositide 3‑kinase/protein kinase B/mechanistic target of rapamycin signaling. In conclusion, vernodalol may be developed as a potential therapeutic compound for the treatment of APL.

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February 2018
Volume 15 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
APA
Wu, W., Han, X., Wu, C., Wei, G., Zheng, G., Li, Y. ... Cai, Z. (2018). Vernodalol mediates antitumor effects in acute promyelocytic leukemia cells. Oncology Letters, 15, 2227-2235. https://doi.org/10.3892/ol.2017.7544
MLA
Wu, W., Han, X., Wu, C., Wei, G., Zheng, G., Li, Y., Yang, Y., Yang, L., He, D., Zhao, Y., Cai, Z."Vernodalol mediates antitumor effects in acute promyelocytic leukemia cells". Oncology Letters 15.2 (2018): 2227-2235.
Chicago
Wu, W., Han, X., Wu, C., Wei, G., Zheng, G., Li, Y., Yang, Y., Yang, L., He, D., Zhao, Y., Cai, Z."Vernodalol mediates antitumor effects in acute promyelocytic leukemia cells". Oncology Letters 15, no. 2 (2018): 2227-2235. https://doi.org/10.3892/ol.2017.7544