Salvianolic acid B suppresses cell proliferation and induces apoptosis in osteosarcoma through p38-mediated reactive oxygen species generation

  • Authors:
    • Zhaoyang Zeng
    • Hua Zhang
    • Xin Wang
    • Kai Liu
    • Tian Li
    • Shaobo Sun
    • Hailong Li
  • View Affiliations

  • Published online on: December 13, 2017     https://doi.org/10.3892/ol.2017.7609
  • Pages: 2679-2685
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Abstract

The present study aimed to investigate the potential anticancer effect and mechanisms of salvianolic acid B on osteosarcoma. Salvianolic acid B suppressed osteosarcoma cell proliferation and induced apoptosis in the osteosarcoma MG63 cell line, and activated the expressions of cleaved caspase‑3, phosphorylated‑tumor protein (p)38 mitogen‑activated protein kinase (p‑p38 MAPK) and phosphorylated‑p53 (p‑p53) proteins in the MG63 cells. Additionally, Salvianolic acid B also increased the level of reactive oxygen species (ROS) generation in the MG63 cells. The silencing of p38 expression inhibited the anticancer effect of salvianolic acid B on the levels of cell proliferation, p‑p53 protein expression and ROS generation level in the MG63 cells. All these data supported the hypothesis that the anticancer effect of salvianolic acid B includes the suppression of cell proliferation and induces apoptosis in MG63 cells, and that p38 is important in the anticancer effect of salvianolic acid B on osteosarcoma cells due to the direct regulation of ROS generation. These data suggest that salvianolic acid B is important in the proliferation of osteosarcoma cells due to the direct regulation of p38‑mediated ROS signaling.

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February 2018
Volume 15 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Zeng, Z., Zhang, H., Wang, X., Liu, K., Li, T., Sun, S., & Li, H. (2018). Salvianolic acid B suppresses cell proliferation and induces apoptosis in osteosarcoma through p38-mediated reactive oxygen species generation. Oncology Letters, 15, 2679-2685. https://doi.org/10.3892/ol.2017.7609
MLA
Zeng, Z., Zhang, H., Wang, X., Liu, K., Li, T., Sun, S., Li, H."Salvianolic acid B suppresses cell proliferation and induces apoptosis in osteosarcoma through p38-mediated reactive oxygen species generation". Oncology Letters 15.2 (2018): 2679-2685.
Chicago
Zeng, Z., Zhang, H., Wang, X., Liu, K., Li, T., Sun, S., Li, H."Salvianolic acid B suppresses cell proliferation and induces apoptosis in osteosarcoma through p38-mediated reactive oxygen species generation". Oncology Letters 15, no. 2 (2018): 2679-2685. https://doi.org/10.3892/ol.2017.7609