Common module analysis reveals prospective targets and mechanisms of pediatric adrenocortical adenoma and carcinoma

Kulshrestha,Anurag; Suman,Shikha

doi:10.3892/ol.2017.7646

Common module analysis reveals prospective targets and mechanisms of pediatric adrenocortical adenoma and carcinoma

Authors:
- Anurag Kulshrestha
- Shikha Suman
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Affiliations: Bioinformatics Division, National Bureau of Animal Genetic Resources, Karnal, Haryana 132001, India, Department of Applied Sciences, Indian Institute of Information Technology, Allahabad, Uttar Pradesh 211012, India
Published online on: December 19, 2017 https://doi.org/10.3892/ol.2017.7646
Pages: 3267-3272

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Abstract

Pediatric adrenocortical carcinoma and adrenocortical adenoma are two rare diseases affecting children. Molecular analyses were performed to identify commonalities in gene expression between the diseases. Differentially expressed genes were identified for the pediatric adrenocortical adenoma and carcinoma tissues, as compared with normal tissues, using the expression dataset. Protein‑protein interaction (PPI) networks were constructed for adenoma and carcinoma disease models, and common modules among the diseases were identified. A total of two common modules with 14 nodes and 20 nodes were revealed among the adenoma and carcinoma networks, respectively. Genes of the common modules were also identified to be the common hub genes of the disease models. Enrichment of the genes of the common modules suggested associations with steroid biosynthesis, the proteasome, cell cycle and metabolic pathways. Modularity, topological and functional analysis of the PPI networks revealed common modules among pediatric adenoma and carcinoma disease models, which provided insight into the underlying disease mechanisms and suggesting prospective targets for future study.

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