Open Access

Notch signaling and non-small cell lung cancer (Review)

  • Authors:
    • Bin Zou
    • Xue‑Liang Zhou
    • Song‑Qing Lai
    • Ji‑Chun Liu
  • View Affiliations

  • Published online on: January 8, 2018     https://doi.org/10.3892/ol.2018.7738
  • Pages: 3415-3421
  • Copyright: © Zou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Lung cancer is the leading cause of cancer‑associated mortality worldwide. Elucidation of the pathogenesis and biology of lung cancer is critical for the design of an effective treatment for patients. Non‑small cell lung cancer (NSCLC) accounts for 80‑85% of lung cancer cases. The abnormal expression of Notch signaling pathway members is a relatively frequent event in NSCLC. The Notch signaling pathway serves important roles in cell fate determination, proliferation, differentiation and apoptosis. Increasing evidence supports the association of Notch signaling dysregulation with various types of malignant tumor, including NSCLC. Several studies have demonstrated that members of the Notch signaling pathway may be potential biomarkers for predicting the progression and prognosis of patients with NSCLC. Furthermore, Notch signaling serves critical roles in the tumorigenesis and treatment resistance of NSCLC cells by promoting the proliferation or inhibiting the apoptosis of NSCLC cells. The present review provides a detailed summary of the roles of Notch signaling in NSCLC.
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March-2018
Volume 15 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Zou B, Zhou XL, Lai SQ and Liu JC: Notch signaling and non-small cell lung cancer (Review). Oncol Lett 15: 3415-3421, 2018
APA
Zou, B., Zhou, X., Lai, S., & Liu, J. (2018). Notch signaling and non-small cell lung cancer (Review). Oncology Letters, 15, 3415-3421. https://doi.org/10.3892/ol.2018.7738
MLA
Zou, B., Zhou, X., Lai, S., Liu, J."Notch signaling and non-small cell lung cancer (Review)". Oncology Letters 15.3 (2018): 3415-3421.
Chicago
Zou, B., Zhou, X., Lai, S., Liu, J."Notch signaling and non-small cell lung cancer (Review)". Oncology Letters 15, no. 3 (2018): 3415-3421. https://doi.org/10.3892/ol.2018.7738