Open Access

Angiogenesis for tumor vascular normalization of Endostar on hepatoma 22 tumor-bearing mice is involved in the immune response

  • Authors:
    • Qingyu Xu
    • Junfei Gu
    • You Lv
    • Jiarui Yuan
    • Nan Yang
    • Juan Chen
    • Chunfei Wang
    • Xuefeng Hou
    • Xiaobin Jia
    • Liang Feng
    • Guowen Yin
  • View Affiliations

  • Published online on: January 5, 2018     https://doi.org/10.3892/ol.2018.7734
  • Pages: 3437-3446
  • Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Tumor vascular normalization involved in immune response is beneficial to the chemotherapy of tumors. Recombinant human endostatin (Endostar), an angiogenesis inhibitor, has been demonstrated to be effective in hepatocellular cancer (HCC). However, its vascular normalization in HCC and the role of the immune response in angiogenesis were unclear. In the present study, effects of Endostar on tumor vascular normalization were evaluated in hepatoma 22 (H22) tumor‑bearing mice. Endostar was able to inhibit the proliferation and infiltration of tumor cells and improve α‑fetoprotein, tumor necrosis factor‑α and cyclic adenosine 5'‑phosphate levels in the serum of H22‑bearing mice, as well as the protein expression levels of the immune factors interferon‑γ and cluster of differentiation (CD)86 in liver tissue. Endostar also exhibited more marked downregulation of the levels of vascular endothelial growth factor, CD31, matrix metalloproteinase (MMP)‑2, MMP‑9 and interleukin‑17 during day 3‑9 treatment, resulting in short‑term normalization of tumor blood vessels. The period of vascular normalization was 3‑9 days. The results of the present study demonstrated that Endostar was able to induce the period of vascular normalization, contributing to a more efficacious means of HCC treatment combined with other chemotherapy, and this effect was associated with the immune response. It may be concluded that Endostar inhibited immunity‑associated angiogenesis behaviors of vascular endothelial cells in response to HCC. The results of the present study provided more reasonable possibility for the combination therapy of Endostar for the treatment of HCC.
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March-2018
Volume 15 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Xu Q, Gu J, Lv Y, Yuan J, Yang N, Chen J, Wang C, Hou X, Jia X, Feng L, Feng L, et al: Angiogenesis for tumor vascular normalization of Endostar on hepatoma 22 tumor-bearing mice is involved in the immune response. Oncol Lett 15: 3437-3446, 2018
APA
Xu, Q., Gu, J., Lv, Y., Yuan, J., Yang, N., Chen, J. ... Yin, G. (2018). Angiogenesis for tumor vascular normalization of Endostar on hepatoma 22 tumor-bearing mice is involved in the immune response. Oncology Letters, 15, 3437-3446. https://doi.org/10.3892/ol.2018.7734
MLA
Xu, Q., Gu, J., Lv, Y., Yuan, J., Yang, N., Chen, J., Wang, C., Hou, X., Jia, X., Feng, L., Yin, G."Angiogenesis for tumor vascular normalization of Endostar on hepatoma 22 tumor-bearing mice is involved in the immune response". Oncology Letters 15.3 (2018): 3437-3446.
Chicago
Xu, Q., Gu, J., Lv, Y., Yuan, J., Yang, N., Chen, J., Wang, C., Hou, X., Jia, X., Feng, L., Yin, G."Angiogenesis for tumor vascular normalization of Endostar on hepatoma 22 tumor-bearing mice is involved in the immune response". Oncology Letters 15, no. 3 (2018): 3437-3446. https://doi.org/10.3892/ol.2018.7734