Glasgow Prognostic Score is superior to ECOG PS as a prognostic factor in patients with gastric cancer with peritoneal seeding

  • Authors:
    • Shu‑Qiang Yuan
    • Run‑Cong Nie
    • Yong‑Ming Chen
    • Hai‑Bo Qiu
    • Xiao‑Ping Li
    • Xiao‑Jiang Chen
    • Li‑Pu Xu
    • Li‑Fang Yang
    • Xiao‑Wei Sun
    • Yuan‑Fang Li
    • Zhi‑Wei Zhou
    • Shi Chen
    • Ying‑Bo Chen
  • View Affiliations

  • Published online on: January 19, 2018     https://doi.org/10.3892/ol.2018.7826
  • Pages:4193-4200
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Abstract

The Glasgow Prognostic Score (GPS) has been shown to be associated with survival rates in patients with advanced cancer. The present study aimed to compare the GPS with the Eastern Cooperative Oncology Group Performance Status (ECOG PS) in patients with gastric cancer with peritoneal seeding. For the investigation, a total of 384 gastric patients with peritoneal metastasis were retrospectively analyzed. Patients with elevated C‑reactive protein (CRP; >10 mg/l) and hypoalbuminemia (<35 mg/l) were assigned a score of 2. Patients were assigned a score of 1 if presenting with only one of these abnormalities, and a score of 0 if neither of these abnormalities were present. The clinicopathologic characteristics and clinical outcomes of patients with peritoneal seeding were analyzed. The results showed that the median overall survival (OS) of patients in the GPS 0 group was longer, compared with that in the GPS 1 and GPS 2 groups (15.50, vs. 10.07 and 7.97 months, respectively; P<0.001). No significant difference was found between the median OS of patients with a good performance status (ECOG <2) and those with a poor (ECOG ≥2) performance status (13.67, vs. 11.80 months; P=0.076). In the subgroup analysis, the median OS in the GPS 0 group was significantly longer, compared with that in the GPS 1 and GPS 2 groups, for the patients receiving palliative chemotherapy and patients without palliative chemotherapy. Multivariate survival analysis demonstrated that CA19‑9, palliative gastrectomy, first‑line chemotherapy and GPS were the prognostic factors predicting OS. In conclusion, the GPS was superior to the subjective assessment of ECOG PS as a prognostic factor in predicting the outcome of gastric cancer with peritoneal seeding.

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April 2018
Volume 15 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Yuan, S., Nie, R., Chen, Y., Qiu, H., Li, X., Chen, X. ... Chen, Y. (2018). Glasgow Prognostic Score is superior to ECOG PS as a prognostic factor in patients with gastric cancer with peritoneal seeding. Oncology Letters, 15, 4193-4200. https://doi.org/10.3892/ol.2018.7826
MLA
Yuan, S., Nie, R., Chen, Y., Qiu, H., Li, X., Chen, X., Xu, L., Yang, L., Sun, X., Li, Y., Zhou, Z., Chen, S., Chen, Y."Glasgow Prognostic Score is superior to ECOG PS as a prognostic factor in patients with gastric cancer with peritoneal seeding". Oncology Letters 15.4 (2018): 4193-4200.
Chicago
Yuan, S., Nie, R., Chen, Y., Qiu, H., Li, X., Chen, X., Xu, L., Yang, L., Sun, X., Li, Y., Zhou, Z., Chen, S., Chen, Y."Glasgow Prognostic Score is superior to ECOG PS as a prognostic factor in patients with gastric cancer with peritoneal seeding". Oncology Letters 15, no. 4 (2018): 4193-4200. https://doi.org/10.3892/ol.2018.7826