Neutrophil-to-lymphocyte ratio predicts overall survival of patients with combined hepatocellular cholangiocarcinoma
- Chaobin He
- Yize Mao
- Xiangming Lao
- Shengping Li
- Xiaojun Lin
Published online on: January 26, 2018
Copyright: © He et al.
This is an open access article distributed under the terms of Creative Commons Attribution License.
The neutrophil-to-lymphocyte ratio (NLR) has been regarded as a prognostic factor in various types of cancer. The present study aimed to identify the association between NLR and combined hepatocellular cholangiocarcinoma (cHCC‑CC) in patients who underwent surgical resection. The present study retrospectively reviewed 59 patients who were diagnosed with cHCC‑CC and treated with surgical resection between January 2000 and October 2014 at the Department of Hepatobiliary and Pancreatic Surgery at Sun Yat‑sen University Cancer Center (Guangzhou, China). The patients were divided into two groups: NLR≤2.75 and NLR>2.75. Patients with stage I and II or stage III and IV disease were classified into early‑ and advanced‑stage groups, respectively, according to the Tumor‑Node‑Metastasis (TNM) staging system. Overall survival time (OS) was estimated using the Kaplan‑Meier method. Univariate and multivariate Cox regression models were used to evaluate the prognostic value of NLR. The NLR value was significantly higher in the HCC advanced‑stage group compared with that in the HCC early‑stage group according to the TNM staging system (3.19 vs. 2.00; P=0.001). The median survival time was 83.6 months in the NLR≤2.75 group and 15 months in the NLR>2.75 group (P=0.004). Upon multivariate analysis, NLR>2.75 was an independent prognostic factor for poor cHCC‑CC outcomes. Overall, the easily evaluated pre‑treatment NLR may be an independent prognostic factor for patients with cHCC-CC treated by surgical resection.