Open Access

Treatment with 20(S)-ginsenoside Rg3 reverses multidrug resistance in A549/DDP xenograft tumors

  • Authors:
    • Chao Liu
    • Quan Gong
    • Ting Chen
    • Juan Lv
    • Zhiping Feng
    • Pengjie Liu
    • Zhiyong Deng
  • View Affiliations

  • Published online on: January 24, 2018     https://doi.org/10.3892/ol.2018.7849
  • Pages:4376-4382
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Multidrug resistance (MDR) is an obstacle for cancer chemotherapy. It was reported that 20(S)-ginsenoside Rg3 (hereafter Rg3) was able to regulate MDR in mouse leukemia cells. The present study investigated the effect of Rg3 on the MDR of A549 lung cancer cells. A cell viability assay revealed that Rg3 treatment increased cisplatin (DDP) cytotoxicity in DDP resistant A549 cells (A549/DDP). Furthermore, Rg3 increases the antitumor effect of DDP on A549/DDP xenograft mice. The expression of MDR‑mediated proteins, including P‑glycoprotein (P‑gp), multidrug resistance‑associated protein (MPR1) and lung resistance protein 1 (LPR1), was detected in tumor tissue of A549/DDP xenograft mice. The results revealed that Rg3 treatment inhibited the expression of these MDR‑associated proteins. Additionally, technetium‑99m labeled hexakis-2-methoxyisobutylisonitrile (99mTc‑MIBI) single‑photon emission computed tomography was used to monitor the effect of Rg3 on cisplatin sensitivity of A549/DDP xenograft tumors. It was observed that uptake of 99mTc‑MIBI was increased by Rg3 treatment, which indicated that Rg3 is able to effectively enhance chemotherapy sensitivity of A549/DDP xenograft tumors. Taken together, these results revealed that Rg3 may be able to reverse MDR of lung cancer via the downregulation of P‑gp, MPR1 and LPR1.

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April 2018
Volume 15 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Liu, C., Gong, Q., Chen, T., Lv, J., Feng, Z., Liu, P., & Deng, Z. (2018). Treatment with 20(S)-ginsenoside Rg3 reverses multidrug resistance in A549/DDP xenograft tumors. Oncology Letters, 15, 4376-4382. https://doi.org/10.3892/ol.2018.7849
MLA
Liu, C., Gong, Q., Chen, T., Lv, J., Feng, Z., Liu, P., Deng, Z."Treatment with 20(S)-ginsenoside Rg3 reverses multidrug resistance in A549/DDP xenograft tumors". Oncology Letters 15.4 (2018): 4376-4382.
Chicago
Liu, C., Gong, Q., Chen, T., Lv, J., Feng, Z., Liu, P., Deng, Z."Treatment with 20(S)-ginsenoside Rg3 reverses multidrug resistance in A549/DDP xenograft tumors". Oncology Letters 15, no. 4 (2018): 4376-4382. https://doi.org/10.3892/ol.2018.7849