Wogonoside inhibits cell growth and induces mitochondrial-mediated autophagy-related apoptosis in human colon cancer cells through the PI3K/AKT/mTOR/p70S6K signaling pathway

  • Authors:
    • Chengzheng Han
    • Guozheng Xing
    • Mengying Zhang
    • Min Zhong
    • Zhen Han
    • Chiyi He
    • Xiaoping Liu
  • View Affiliations

  • Published online on: January 24, 2018     https://doi.org/10.3892/ol.2018.7852
  • Pages:4463-4470
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Abstract

Wogonoside, the main effective constituent of traditional Chinese medicine Scutellaria, belongs to the glucuronide family, with various functions, including detoxification, anti‑inflammation and nourishing gallbladder, lowering blood pressure, diuresis and anti‑allergic reactions. However, the effects of wogonoside on human colon cancer cells remain unclear. The present study aimed to investigate the anticancer effect of wogonoside on human colon cancer cells in vitro and its anticancer mechanisms. The results demonstrated that wogonoside significantly inhibited cell growth, induced apoptosis and mitochondrial‑mediated autophagy of colon cancer cells. Furthermore, the results revealed that wogonoside significantly increased caspase‑3 and caspase‑9 expression levels, induced apoptosis regulator Bax/Bcl‑2 and microtubule‑associated protein 1A/1B‑light chain 3 protein expression, suppressed the phosphatidylinositol 3 kinase (PI3K)/RAC‑α serine/threonine‑protein kinase (Akt)/mechanistic target of rapamycin (mTOR)/p70 S6 kinase (p70S6K) signaling pathway and induced p62 protein expression in colon cancer cells. In conclusion, these results demonstrated that wogonoside inhibits cell growth and induces mitochondrial mediated autophagy‑related apoptosis in human colon cancer cells through modulation of the PI3K/Akt/mTOR/p70S6K signaling pathway.

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April 2018
Volume 15 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
APA
Han, C., Xing, G., Zhang, M., Zhong, M., Han, Z., He, C., & Liu, X. (2018). Wogonoside inhibits cell growth and induces mitochondrial-mediated autophagy-related apoptosis in human colon cancer cells through the PI3K/AKT/mTOR/p70S6K signaling pathway. Oncology Letters, 15, 4463-4470. https://doi.org/10.3892/ol.2018.7852
MLA
Han, C., Xing, G., Zhang, M., Zhong, M., Han, Z., He, C., Liu, X."Wogonoside inhibits cell growth and induces mitochondrial-mediated autophagy-related apoptosis in human colon cancer cells through the PI3K/AKT/mTOR/p70S6K signaling pathway". Oncology Letters 15.4 (2018): 4463-4470.
Chicago
Han, C., Xing, G., Zhang, M., Zhong, M., Han, Z., He, C., Liu, X."Wogonoside inhibits cell growth and induces mitochondrial-mediated autophagy-related apoptosis in human colon cancer cells through the PI3K/AKT/mTOR/p70S6K signaling pathway". Oncology Letters 15, no. 4 (2018): 4463-4470. https://doi.org/10.3892/ol.2018.7852