Expression pattern of human SERPINE2 in a variety of human tumors
- Ying Yang
- Xiangke Xin
- Xing Fu
- Danmei Xu
Published online on: January 18, 2018
Serine proteinase inhibitor, clade E member 2 (SERPINE2), also known as protease nexin‑1 (PN‑1), is a member of the serpin family. Despite several reported roles of SERPINE2 in tumor development the histological distribution of SERPINE2 and its expression levels in a large variety of tumors remains unclear. Through expressed sequence tag database analysis, immunohistochemical staining of tissue microarrays and a literature review, it was revealed that SERPINE2 expression varied according to growth stages and tissue types. SERPINE2 is differentially expressed in a number of tumors and their normal tissue counterparts. SERPINE2 is identified most abundantly in adenocarcinomas. SERPINE2 serves diverse roles in a variety of tumors and therefore may serve as a promising biomarker for tumor diagnosis and prognosis.