Expression pattern of human SERPINE2 in a variety of human tumors

  • Authors:
    • Ying Yang
    • Xiangke Xin
    • Xing Fu
    • Danmei Xu
  • View Affiliations

  • Published online on: January 18, 2018     https://doi.org/10.3892/ol.2018.7819
  • Pages: 4523-4530
Metrics: HTML 0 views | PDF 0 views     Cited By (CrossRef): 0 citations

Abstract

Serine proteinase inhibitor, clade E member 2 (SERPINE2), also known as protease nexin‑1 (PN‑1), is a member of the serpin family. Despite several reported roles of SERPINE2 in tumor development the histological distribution of SERPINE2 and its expression levels in a large variety of tumors remains unclear. Through expressed sequence tag database analysis, immunohistochemical staining of tissue microarrays and a literature review, it was revealed that SERPINE2 expression varied according to growth stages and tissue types. SERPINE2 is differentially expressed in a number of tumors and their normal tissue counterparts. SERPINE2 is identified most abundantly in adenocarcinomas. SERPINE2 serves diverse roles in a variety of tumors and therefore may serve as a promising biomarker for tumor diagnosis and prognosis.

Related Articles

Journal Cover

April 2018
Volume 15 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Yang, Y., Xin, X., Fu, X., & Xu, D. (2018). Expression pattern of human SERPINE2 in a variety of human tumors. Oncology Letters, 15, 4523-4530. https://doi.org/10.3892/ol.2018.7819
MLA
Yang, Y., Xin, X., Fu, X., Xu, D."Expression pattern of human SERPINE2 in a variety of human tumors". Oncology Letters 15.4 (2018): 4523-4530.
Chicago
Yang, Y., Xin, X., Fu, X., Xu, D."Expression pattern of human SERPINE2 in a variety of human tumors". Oncology Letters 15, no. 4 (2018): 4523-4530. https://doi.org/10.3892/ol.2018.7819