MicroRNA-33a downregulation is associated with tumorigenesis and poor prognosis in patients with hepatocellular carcinoma

  • Authors:
    • Ru‑Ting Xie
    • Xian‑Ling Cong
    • Xiao‑Ming Zhong
    • Ping Luo
    • Hui‑Qiong Yang
    • Gai‑Xia Lu
    • Pei Luo
    • Zheng‑Yan Chang
    • Ran Sun
    • Ting‑Miao Wu
    • Zhong‑Wei Lv
    • Da Fu
    • Yu‑Shui Ma
  • View Affiliations

  • Published online on: January 29, 2018     https://doi.org/10.3892/ol.2018.7892
  • Pages: 4571-4577
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Abstract

In order to examine the prognostic significance of miR‑33a in patients with hepatocellular carcinoma (HCC), total RNA was extracted from 149 HCC biopsies, 36 of which were paired with para‑carcinoma tissues, and miR‑33a expression was measured by reverse transcription-quantitative polymerase chain reaction. The results demonstrated that miR‑33a expression was decreased in HCC biopsies compared with normal liver tissue samples. It was also demonstrated that miR‑33a expression was significantly associated with tumor foci number. Furthermore, overall and progression‑free survival time was decreased in patients expressing low miR‑33a with multiple tumor foci. Taken together, the low expression of miR‑33a may be a potential risk factor for HCC.

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April 2018
Volume 15 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
APA
Xie, R., Cong, X., Zhong, X., Luo, P., Yang, H., Lu, G. ... Ma, Y. (2018). MicroRNA-33a downregulation is associated with tumorigenesis and poor prognosis in patients with hepatocellular carcinoma. Oncology Letters, 15, 4571-4577. https://doi.org/10.3892/ol.2018.7892
MLA
Xie, R., Cong, X., Zhong, X., Luo, P., Yang, H., Lu, G., Luo, P., Chang, Z., Sun, R., Wu, T., Lv, Z., Fu, D., Ma, Y."MicroRNA-33a downregulation is associated with tumorigenesis and poor prognosis in patients with hepatocellular carcinoma". Oncology Letters 15.4 (2018): 4571-4577.
Chicago
Xie, R., Cong, X., Zhong, X., Luo, P., Yang, H., Lu, G., Luo, P., Chang, Z., Sun, R., Wu, T., Lv, Z., Fu, D., Ma, Y."MicroRNA-33a downregulation is associated with tumorigenesis and poor prognosis in patients with hepatocellular carcinoma". Oncology Letters 15, no. 4 (2018): 4571-4577. https://doi.org/10.3892/ol.2018.7892