Co-existence of isodicentric Ph chromosomes and the three-way Ph chromosome variant t(3;9;22)(p21;q34;q11) in a rare case of chronic myeloid leukemia

  • Authors:
    • Qian Li
    • Xiao‑Ji Lin
    • Hui Chen
    • Jian Gong
    • Zhen Li
    • Xiang‑Nan Chen
  • View Affiliations

  • Published online on: January 26, 2018     https://doi.org/10.3892/ol.2018.7866
  • Pages:4599-4603
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Abstract

More than 90% of patients with chronic myeloid leukemia (CML) have the chromosomal translocation t(9;22)(q34;q11), while 5‑8% of patients have complex variant translocations that have previously been thought not to affect the efficacy of imatinib therapy. The present study reports a patient with CML in B‑lymphoid blast crisis who had a rare three‑way Philadelphia (Ph) variant t(3;9;22)(p21;q34;q11), in addition to isodicentric Ph chromosomes. The patient was initially treated with imatinib for >2 months with a very poor response. When no T315I or F317L mutations in the ABL proto‑oncogene 1 region were detected, the patient received dasatinib treatment (140 mg daily) and achieved a complete hematologic response. Following allo‑hematopoietic stem cell transplantation, the patient displayed clinical, hematological and cytogenetic remission, with complete molecular response and complete donor chimerism, and stopped taking dasatinib at the last follow‑up. The present data suggest that BCR‑ABL gene amplification may be associated with imatinib resistance, which can be overcome with dasatinib. The present analysis suggests an alternative therapy strategy for CML involving isodicentric Ph chromosomes.

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April 2018
Volume 15 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Li, Q., Lin, X., Chen, H., Gong, J., Li, Z., & Chen, X. (2018). Co-existence of isodicentric Ph chromosomes and the three-way Ph chromosome variant t(3;9;22)(p21;q34;q11) in a rare case of chronic myeloid leukemia. Oncology Letters, 15, 4599-4603. https://doi.org/10.3892/ol.2018.7866
MLA
Li, Q., Lin, X., Chen, H., Gong, J., Li, Z., Chen, X."Co-existence of isodicentric Ph chromosomes and the three-way Ph chromosome variant t(3;9;22)(p21;q34;q11) in a rare case of chronic myeloid leukemia". Oncology Letters 15.4 (2018): 4599-4603.
Chicago
Li, Q., Lin, X., Chen, H., Gong, J., Li, Z., Chen, X."Co-existence of isodicentric Ph chromosomes and the three-way Ph chromosome variant t(3;9;22)(p21;q34;q11) in a rare case of chronic myeloid leukemia". Oncology Letters 15, no. 4 (2018): 4599-4603. https://doi.org/10.3892/ol.2018.7866