PRR4: A novel downregulated gene in laryngeal cancer

  • Authors:
    • Seda Ekizoglu
    • Turgut Ulutin
    • Jalal Guliyev
    • Nur Buyru
  • View Affiliations

  • Published online on: January 29, 2018     https://doi.org/10.3892/ol.2018.7888
  • Pages: 4669-4675
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Abstract

Head and neck squamous cell carcinomas (HNSCC) are a diverse group of tumor types, including neoplasia of the paranasal sinuses, oral cavity, trachea, pharynx and larynx. Laryngeal cancer is the most common type of HNSCC. The proline‑rich 4 (PRR4) protein is synthesized in the acinar cells of human lacrimal glands. Previous studies have demonstrated that PRR4 may function as an antimicrobial protein protecting the ocular surface and the oral cavity. In order to determine differentially expressed genes (DEGs) in laryngeal tumors, a GeneFishing Assay was performed; 27 DEGs were identified. The PRR4 gene expression level in laryngeal tissue samples obtained from 90 patients, and the saliva of 25 healthy smokers and 25 non‑smokers, was investigated using reverse transcription‑quantitative polymerase chain reaction. It was revealed that PRR4 gene expression was decreased in 65/90 tumor tissues (72.2%) compared with normal tissues. No significant difference was identified between the healthy smoker and the non‑smoker groups in terms of PRR4 gene expression. The results of the present study indicated that the PRR4 gene may serve an important role in laryngeal carcinogenesis.

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April 2018
Volume 15 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Ekizoglu, S., Ulutin, T., Guliyev, J., & Buyru, N. (2018). PRR4: A novel downregulated gene in laryngeal cancer. Oncology Letters, 15, 4669-4675. https://doi.org/10.3892/ol.2018.7888
MLA
Ekizoglu, S., Ulutin, T., Guliyev, J., Buyru, N."PRR4: A novel downregulated gene in laryngeal cancer". Oncology Letters 15.4 (2018): 4669-4675.
Chicago
Ekizoglu, S., Ulutin, T., Guliyev, J., Buyru, N."PRR4: A novel downregulated gene in laryngeal cancer". Oncology Letters 15, no. 4 (2018): 4669-4675. https://doi.org/10.3892/ol.2018.7888