NIPAAm-MMA nanoparticle-encapsulated visnagin ameliorates myocardial ischemia/reperfusion injury through the promotion of autophagy and the inhibition of apoptosis

Fu,Hairong; Li,Xiaoshan; Tan,Jiahua

doi:10.3892/ol.2018.7922

NIPAAm-MMA nanoparticle-encapsulated visnagin ameliorates myocardial ischemia/reperfusion injury through the promotion of autophagy and the inhibition of apoptosis

Authors:
- Hairong Fu
- Xiaoshan Li
- Jiahua Tan
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Affiliations: Department of Physiology, Chongqing Three Gorges Medical College, Chongqing 404120, P.R. China, Department of Pathology, Chongqing Three Gorges Medical College, Chongqing 404120, P.R. China, Department of Physical Education, Chongqing Three Gorges Medical College, Chongqing 404120, P.R. China
Published online on: February 1, 2018 https://doi.org/10.3892/ol.2018.7922
Pages: 4827-4836
Copyright: © Fu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The main method for the treatment of acute myocardial infarction (AMI) is percutaneous coronary intervention; however percutaneous coronary intervention will induce ischemia/reperfusion (IR) injury, resulting in the loss of cardiac function and cardiomyocyte death. An effective drug to target this condition is necessary. N‑isopropylacrylamide and methacrylic acid were used to synthesize drug delivery nanoparticles (NP) containing the natural compound visnagin for IR injury treatment. It was demonstrated that NP containing fluorescein isothiocyanate localized to the site of myocardial IR, and that NP‑visnagin treatment induced cardioprotection, reducing the size of the MI and ameliorating cardiac dysfunction through the induction of autophagy and the inhibition of apoptosis. In the future, visnagin may be suitable as a drug for IR injury treatment, and NP may be an effective drug delivery system.

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