Prognostic significance of copy number alterations detected by multi‑link probe amplification of multiple genes in adult acute lymphoblastic leukemia

  • Authors:
    • Qiuyun Fang
    • Tian Yuan
    • Yan Li
    • Juan Feng
    • Xiaoyuan Gong
    • Qinghua Li
    • Xingli Zhao
    • Kaiqi Liu
    • Kejing Tang
    • Zheng Tian
    • Qi Zhang
    • Ying Wang
    • Bingcheng Liu
    • Min Wang
    • Kun Ru
    • Jianxiang Wang
    • Yingchang Mi
  • View Affiliations

  • Published online on: February 7, 2018     https://doi.org/10.3892/ol.2018.7985
  • Pages: 5359-5367
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The multiplex ligation-dependent probe amplification (MLPA) method was used to detect the copy number alterations (CNAs) of IKAROS family zinc finger 1 (IKZF1), paired box 5 (PAX5), ETS variant 6 (ETV6), RB transcriptional corepressor 1 (RB1), BTG anti‑proliferation factor 1 (BTG1), early B‑cell factor 1 (EBF1), cyclin dependent kinase inhibitor 2A/2B (CDKN2A/2B) and cytokine receptor like factor 2 (CRLF2) genes in 87 adults with acute lymphoblastic leukemia (ALL) in China. The effects of CNAs on prognosis were analyzed. Gene deletions were detected in 58/87 (66.7%) ALL patients. The most common deletions were observed in the following genes: IKZF1 (40.6%), CDKN2A (31.9%), CDKN2B (29%), PAX5 (21.7%), RB1 (14.5%) and BTG1 (10.1%). B cell‑ALL (B‑ALL) patients with CDKN2A/2B deletions exhibited poor 2‑year overall survival (OS; P=0.055) and relapse‑free survival (RFS; P=0.054) rates. CDKN2A/2B deletions were associated with poor 2‑year OS (P=0.045) and RFS (P=0.071) rates in Philadelphia chromosome positive (Ph+) B‑ALL patients, as well as in the high risk (HR) B‑ALL group (P=0.037 and P=0.047, respectively). Patients with PAX5 deletions displayed poor 2‑year OS (P=0.004) and RFS (P=0.016) rates in Philadelphia chromosome negative (Ph‑) B‑ALL patients. Patients with ≥3 gene deletions exhibited a poorer prognosis than other patients (OS, P=0.001; RFS, 0.002).
View Figures
View References

Related Articles

Journal Cover

April-2018
Volume 15 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Fang Q, Yuan T, Li Y, Feng J, Gong X, Li Q, Zhao X, Liu K, Tang K, Tian Z, Tian Z, et al: Prognostic significance of copy number alterations detected by multi‑link probe amplification of multiple genes in adult acute lymphoblastic leukemia. Oncol Lett 15: 5359-5367, 2018
APA
Fang, Q., Yuan, T., Li, Y., Feng, J., Gong, X., Li, Q. ... Mi, Y. (2018). Prognostic significance of copy number alterations detected by multi‑link probe amplification of multiple genes in adult acute lymphoblastic leukemia. Oncology Letters, 15, 5359-5367. https://doi.org/10.3892/ol.2018.7985
MLA
Fang, Q., Yuan, T., Li, Y., Feng, J., Gong, X., Li, Q., Zhao, X., Liu, K., Tang, K., Tian, Z., Zhang, Q., Wang, Y., Liu, B., Wang, M., Ru, K., Wang, J., Mi, Y."Prognostic significance of copy number alterations detected by multi‑link probe amplification of multiple genes in adult acute lymphoblastic leukemia". Oncology Letters 15.4 (2018): 5359-5367.
Chicago
Fang, Q., Yuan, T., Li, Y., Feng, J., Gong, X., Li, Q., Zhao, X., Liu, K., Tang, K., Tian, Z., Zhang, Q., Wang, Y., Liu, B., Wang, M., Ru, K., Wang, J., Mi, Y."Prognostic significance of copy number alterations detected by multi‑link probe amplification of multiple genes in adult acute lymphoblastic leukemia". Oncology Letters 15, no. 4 (2018): 5359-5367. https://doi.org/10.3892/ol.2018.7985