Correlation between CT features and liver function and p53expression in hepatitis, cirrhosis and hepatocellular carcinoma

Hu,Yahui; Wu,Jing; Li,Sha; Zhao ,Xiaoxiao

doi:10.3892/ol.2018.9144

Correlation between CT features and liver function and p53expression in hepatitis, cirrhosis and hepatocellular carcinoma

Authors:
- Yahui Hu
- Jing Wu
- Sha Li
- Xiaoxiao Zhao
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Affiliations: Department of Nuclear Medicine, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan 450000, P.R. China
Published online on: July 12, 2018 https://doi.org/10.3892/ol.2018.9144
Pages: 4297-4302
Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

This study aimed to investigate the correlation between CT features and liver function and p53 expression in hepatitis, cirrhosis and hepatocellular carcinoma (HCC). Forty patients with HCC, 30 patients with cirrhosis and 30 patients with chronic hepatitis were enrolled between December, 2015 and December, 2016. At the same time, normal liver tissues collected from 30 patients with hepatic hemangioma were used as the normal control group. All the patients were scanned by CT. Average body surface area, left outer lobe and caudate lobe volume, and the proportions of left outer lobe and caudate lobe to the whole liver were calculated. Biochemical indexes of liver function were determined. The pathological tissues of all the subjects were analyzed. Compared with the control group, total liver volume of the HCC group was significantly reduced (P<0.05). Compared with the HCC group, the volume of the left outer lobe increased in the hepatitis group and the cirrhosis group. Compared with control group, caudate lobe volume increased significantly in the hepatitis group (P<0.05). Compared with the control group, the volume of the left outer lobe and the proportion of caudate lobe to the whole liver volume was significantly increased in all three groups (P<0.05). Liver function‑related indicators in the HCC and cirrhosis groups were significantly different from those in the control group (P<0.05). The expression level of p53 in HCC was significantly higher than that in the control group (P<0.05). The accuracy of diagnosis by using both p53 and CT was higher than the use of p53 or CT alone. CT can accurately measure the volume of each lobe of the liver, and p53 has important clinical values in the diagnosis of liver diseases. Thus, the reasonable combination of the two can effectively improve the diagnostic accuracy.

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1	Li H, Wang S, Wang G, Zhang Z, Wu X, Zhang T, Fu B and Chen G: Yes-associated protein expression is a predictive marker for recurrence of hepatocellular carcinoma after liver transplantation. Dig Surg. 31:468–478. 2014. View Article : Google Scholar : PubMed/NCBI
2	Ji X, Zhang Q, Du Y, Liu W, Li Z, Hou X and Cao G: Somatic mutations, viral integration and epigenetic modification in the evolution of hepatitis B virus-induced hepatocellular carcinoma. Curr Genomics. 15:469–480. 2014. View Article : Google Scholar : PubMed/NCBI
3	Bahnassy AA, Zekri ARN, El-Bastawisy A, Fawzy A, Shetta M, Hussein N, Omran D, Ahmed AAS and El-Labbody SS: Circulating tumor and cancer stem cells in hepatitis C virus-associated liver disease. World J Gastroenterol. 20:18240–18248. 2014. View Article : Google Scholar : PubMed/NCBI
4	Chen X, Jiang W, Yue C, Zhang W, Tong C, Dai D, Cheng B, Huang C and Lu L: Heparanase contributes to trans-endothelial migration of hepatocellular carcinoma cells. J Cancer. 8:3309–3317. 2017. View Article : Google Scholar : PubMed/NCBI
5	Gehrmann M, Cervello M, Montalto G, Cappello F, Gulino A, Knape C, Specht HM and Multhoff G: Heat shock protein 70 serum levels differ significantly in patients with chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Front Immunol. 5:3072014. View Article : Google Scholar : PubMed/NCBI
6	Kang GH, Lee BS, Lee ES, Kim SH, Lee HY and Kang DY: Prognostic significance of p53, mTOR, c-Met, IGF-1R, and HSP70 overexpression after the resection of hepatocellular carcinoma. Gut Liver. 8:79–87. 2014. View Article : Google Scholar : PubMed/NCBI
7	Tremosini S, Forner A, Boix L, Vilana R, Bianchi L, Reig M, Rimola J, Rodríguez-Lope C, Ayuso C, Solé M, et al: Prospective validation of an immunohistochemical panel (glypican 3, heat shock protein 70 and glutamine synthetase) in liver biopsies for diagnosis of very early hepatocellular carcinoma. Gut. 61:1481–1487. 2012. View Article : Google Scholar : PubMed/NCBI
8	Liu K, Zhao X, Gu J, Wu J, Zhang H and Li Y: Effects of 12C6⁺ heavy ion beam irradiation on the p53 signaling pathway in HepG2 liver cancer cells. Acta Biochim Biophys Sin (Shanghai). 49:989–998. 2017. View Article : Google Scholar : PubMed/NCBI
9	Liu K, Lee J, Kim JY, Wang L, Tian Y, Chan ST, Cho C, Machida K, Chen D and Ou JJ: Mitophagy controls the activities of tumor suppressor p53 to regulate hepatic cancer stem cells. Mol Cell. 68(281–292): e52017.
10	Chai Y, Xiaoyu L and Haiyan W: Correlation between expression levels of PTEN and p53 genes and the clinical features of HBsAg-positive liver cancer. J BUON. 22:942–946. 2017.PubMed/NCBI
11	EI-Emshaty HM, Saad EA, Toson EA, Malak Abdel CA and Gadelhak NA: Apoptosis and cell proliferation: Correlation with BCL-2 and p53 oncoprotein expression in human hepatocellular carcinoma. Hepatogastroenterology. 61:1393–1401. 2014.PubMed/NCBI
12	Meng X, Franklin DA, Dong J and Zhang Y: MDM2-p53 pathway in hepatocellular carcinoma. Cancer Res. 74:7161–7167. 2014. View Article : Google Scholar : PubMed/NCBI
13	Lagana SM, Salomao M, Bao F, Moreira RK, Lefkowitch JH and Remotti HE: Utility of an immunohistochemical panel consisting of glypican-3, heat-shock protein-70, and glutamine synthetase in the distinction of low-grade hepatocellular carcinoma from hepatocellular adenoma. Appl Immunohistochem Mol Morphol. 21:170–176. 2013.PubMed/NCBI
14	Fu Y, Xu X, Huang D, Cui D, Liu L, Liu J, He Z, Liu J, Zheng S and Luo Y: Plasma heat shock protein 90alpha as a biomarker for the diagnosis of liver cancer: An official, large-scale, and multicenter clinical trial. EBioMedicine. 24:56–63. 2017. View Article : Google Scholar : PubMed/NCBI
15	Tawada A, Kanda T and Yokosuka O: Current and future directions for treating hepatitis B virus infection. World J Hepatol. 7:1541–1552. 2015. View Article : Google Scholar : PubMed/NCBI
16	Abdelfattah MR, Abaalkhail F and Al-Manea H: Misdiagnosed or incidentally detected hepatocellular carcinoma in explanted livers: Lessons learned. Ann Transplant. 20:366–372. 2015. View Article : Google Scholar : PubMed/NCBI
17	Lun-Gen L: Antiviral therapy of liver cirrhosis related to hepatitis B virus infection. J Clin Transl Hepatol. 2:197–201. 2014.PubMed/NCBI
18	Zhang D and Xu A: Application of dual-source CT perfusion imaging and MRI for the diagnosis of primary liver cancer. Oncol Lett. 14:5753–5758. 2017.PubMed/NCBI
19	Moreira AJ, Rodrigues G, Bona S, Cerski CT, Marroni CA, Mauriz JL, González-Gallego J and Marroni NP: Oxidative stress and cell damage in a model of precancerous lesions and advanced hepatocellular carcinoma in rats. Toxicol Rep. 2:333–340. 2014. View Article : Google Scholar : PubMed/NCBI
20	Wu W, Liu S, Liang Y, Zhou Z, Bian W and Liu X: Stress hormone cortisol enhances Bcl-2 like-12 expression to inhibit p53 in hepatocellular carcinoma cells. Dig Dis Sci. 62:3495–3500. 2017. View Article : Google Scholar : PubMed/NCBI