Genetic influence of cytokine polymorphisms on the clinical outcome of Japanese gastrointestinal cancer patients in palliative care

Hishida,Asahi; Okugawa,Yoshinaga; Morimoto,Yuhki; Shirai,Yumiko; Okamoto,Kyoko; Momokita,Sachiko; Ogawa,Aki; Tanaka,Koji; Nishikawa,Ryutaro; Toiyama,Yuji; Inoue,Yasuhiro; Sakurai,Hiroyuki; Urata,Hisashi; Tanaka,Motoyoshi; McMillan,Donald  C.; Miki,Chikao

doi:10.3892/ol.2018.9614

Genetic influence of cytokine polymorphisms on the clinical outcome of Japanese gastrointestinal cancer patients in palliative care

Authors:
- Asahi Hishida
- Yoshinaga Okugawa
- Yuhki Morimoto
- Yumiko Shirai
- Kyoko Okamoto
- Sachiko Momokita
- Aki Ogawa
- Koji Tanaka
- Ryutaro Nishikawa
- Yuji Toiyama
- Yasuhiro Inoue
- Hiroyuki Sakurai
- Hisashi Urata
- Motoyoshi Tanaka
- Donald C. McMillan
- Chikao Miki
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Affiliations: Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466‑8550, Japan, Department of Surgery, Iga City General Hospital, Iga, Mie 518‑0823, Japan, Department of Nutrition, Iga City General Hospital, Iga, Mie 518‑0823, Japan, Department of Nursing, Iga City General Hospital, Iga, Mie 518‑0823, Japan, Department of Biochemical Laboratory, Iga City General Hospital, Iga, Mie 518‑0823, Japan, Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Tsu, Mie 514‑8507, Japan, Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Tsu, Mie 514‑8507, Japan, Department of Medical Oncology, Iga City General Hospital, Iga, Mie 518‑0823, Japan, Department of Surgical Science, University of Glasgow School of Medicine, Dentistry and Nursing, Glasgow G4 0SF, UK
Published online on: October 24, 2018 https://doi.org/10.3892/ol.2018.9614
Pages: 623-629

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Abstract

Gastrointestinal cancer is one of the most common causes of mortality globally. The present study examined the influence of cytokine genetic polymorphisms [interleukin (IL)‑1B C‑31T, IL‑1RN VNTR, IL‑6 C‑634G, IL‑8 T‑251A, IL‑10 T‑819C and IL‑10 A‑1082G] on clinical outcomes in patients with gastrointestinal cancer in palliative care. A total of 59 patients with gastrointestinal cancer who were admitted to Iga City General Hospital were analyzed. Genotyping was conducted using a polymerase chain reaction with confronting two‑pair primers. Patients with at least one IL‑1RN 2 allele demonstrated a significantly better survival (P=0.0275) while those with IL‑6‑634 G/G demonstrated a worse survival (P=0.0024). Multivariate analyses using the Cox proportional hazard model revealed that those with at least one IL‑1RN 2 allele, IL‑6‑634 G/G or IL‑10‑1082 A/G had a significantly elevated adjusted hazard ratio of 9.20 (P=0.014), 41.01 (P=0.001) or 6.49 (P=0.046), respectively, compared with those with each homozygous wild‑type polymorphism. In addition, the evaluation of weight loss by genotype revealed the potential influence of IL‑10 T‑819C genotype (P=0.072). IL‑1RN, IL‑6 and IL‑10 polymorphisms were associated with the survival of patients with gastrointestinal cancer, suggesting the clinical feasibility of genetic testing in patients with gastrointestinal cancer in palliative care.

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