Open Access

SUN2: A potential therapeutic target in cancer (Review)

  • Authors:
    • Xin Chen
    • Yu Chen
    • Hui‑Min Huang
    • Hai‑Di Li
    • Fang‑Tian Bu
    • Xue‑Yin Pan
    • Yang Yang
    • Wan‑Xia Li
    • Xiao‑Feng Li
    • Cheng Huang
    • Xiao‑Ming Meng
    • Jun Li
  • View Affiliations

  • Published online on: November 27, 2018     https://doi.org/10.3892/ol.2018.9764
  • Pages: 1401-1408
  • Copyright : © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

The incidence of cancer is increasing at an alarming rate despite recent advances in prevention strategies, diagnostics and therapeutics for various types of cancer. The identification of novel biomarkers to aid in prognosis and treatment for cancer is urgently required. Uncontrolled proliferation and dysregulated apoptosis are characteristics exhibited by cancer cells in the initiation of various types of cancer. Notably, aberrant expression of crucial oncogenes or cancer suppressors is a defining event in cancer occurrence. Research has demonstrated that SAD1/UNC84 domain protein‑2 (SUN2) serves a suppressive role in breast cancer, atypical teratoid/rhabdoid tumors and lung cancer progression. Furthermore, SUN2 inhibits cancer cell proliferation, migration and promotes apoptosis. Recent reports have also shown that SUN2 serves prominent roles in resistance to the excessive DNA damage that destabilizes the genome and promotes cancer development, and these functions of SUN2 are critical for evading initiation of cancer. Additionally, increasing evidence has demonstrated that SUN2 is involved in maintaining cell nuclear structure and appears to be a central component for organizing the natural nuclear architecture in cancer cells. The focus of the present review is to provide an overview on the pharmacological functions of SUN2 in cancers. These findings suggest that SUN2 may serve as a promising therapeutic target and novel predictive marker in various types of cancer.
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February-2019
Volume 17 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Chen X, Chen Y, Huang HM, Li HD, Bu FT, Pan XY, Yang Y, Li WX, Li XF, Huang C, Huang C, et al: SUN2: A potential therapeutic target in cancer (Review). Oncol Lett 17: 1401-1408, 2019
APA
Chen, X., Chen, Y., Huang, H., Li, H., Bu, F., Pan, X. ... Li, J. (2019). SUN2: A potential therapeutic target in cancer (Review). Oncology Letters, 17, 1401-1408. https://doi.org/10.3892/ol.2018.9764
MLA
Chen, X., Chen, Y., Huang, H., Li, H., Bu, F., Pan, X., Yang, Y., Li, W., Li, X., Huang, C., Meng, X., Li, J."SUN2: A potential therapeutic target in cancer (Review)". Oncology Letters 17.2 (2019): 1401-1408.
Chicago
Chen, X., Chen, Y., Huang, H., Li, H., Bu, F., Pan, X., Yang, Y., Li, W., Li, X., Huang, C., Meng, X., Li, J."SUN2: A potential therapeutic target in cancer (Review)". Oncology Letters 17, no. 2 (2019): 1401-1408. https://doi.org/10.3892/ol.2018.9764