Role of RNA‑binding protein 5 in the diagnosis and chemotherapeutic response of lung cancer (Review)

  • Authors:
    • Yanling Xu
    • Zhenzhong Su
    • Junyao Li
    • Qi Wang
    • Guangping Meng
    • Yu Zhang
    • Wen Yang
    • Jie Zhang
    • Peng Gao
  • View Affiliations

  • Published online on: December 10, 2018     https://doi.org/10.3892/ol.2018.9818
  • Pages: 2013-2019
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Abstract

Lung cancer remains one of the leading causes of cancer‑associated mortality in the world. Lung carcinogenesis is frequently associated with deletions or the loss of heterozygosity at the critical chromosomal region 3p21.3, where RNA‑binding protein 5 (RBM5) is localized. RBM5 regulates cell growth, cell cycle progression and apoptosis in cell homeostasis. In the lungs, altered RBM5 protein expression leads to alterations in cell growth and apoptosis, with subsequent lung pathogenesis and varied responses to treatment in patients with lung cancer. Detection of RBM5 expression may be a tumor marker for diagnosis, prediction and treatment response in lung cancer, and may be developed as a potential therapeutic target for drug resistant lung cancer. This review discusses the most recent progress on the role of RBM5 in lung cancer.
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February-2019
Volume 17 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Xu Y, Su Z, Li J, Wang Q, Meng G, Zhang Y, Yang W, Zhang J and Gao P: Role of RNA‑binding protein 5 in the diagnosis and chemotherapeutic response of lung cancer (Review). Oncol Lett 17: 2013-2019, 2019
APA
Xu, Y., Su, Z., Li, J., Wang, Q., Meng, G., Zhang, Y. ... Gao, P. (2019). Role of RNA‑binding protein 5 in the diagnosis and chemotherapeutic response of lung cancer (Review). Oncology Letters, 17, 2013-2019. https://doi.org/10.3892/ol.2018.9818
MLA
Xu, Y., Su, Z., Li, J., Wang, Q., Meng, G., Zhang, Y., Yang, W., Zhang, J., Gao, P."Role of RNA‑binding protein 5 in the diagnosis and chemotherapeutic response of lung cancer (Review)". Oncology Letters 17.2 (2019): 2013-2019.
Chicago
Xu, Y., Su, Z., Li, J., Wang, Q., Meng, G., Zhang, Y., Yang, W., Zhang, J., Gao, P."Role of RNA‑binding protein 5 in the diagnosis and chemotherapeutic response of lung cancer (Review)". Oncology Letters 17, no. 2 (2019): 2013-2019. https://doi.org/10.3892/ol.2018.9818