Open Access

Sodium orthovanadate inhibits growth and triggers apoptosis of human anaplastic thyroid carcinoma cells in vitro and in vivo

  • Authors:
    • Qingan Yu
    • Wenjing Jiang
    • Dan Li
    • Mingqi Gu
    • Kunpeng Liu
    • Liqian Dong
    • Chaoqun Wang
    • Hongchi Jiang
    • Wenjie Dai
  • View Affiliations

  • Published online on: February 28, 2019     https://doi.org/10.3892/ol.2019.10090
  • Pages: 4255-4262
  • Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Vanadium and its compounds exhibit concentration‑ and time‑dependent anticancer effects on various types of tumor; however, the effects of sodium orthovanadate (SOV) on anaplastic thyroid carcinoma (ATC) have not yet been reported. In the present study, the anticancer effects of SOV on ATC were evaluated. In vitro experiments, including cell viability assays, plate colony formation assays, cell cycle analysis and apoptosis analysis were used to study the role of SOV in ATC. Using in vivo experiments, the effects of SOV on the growth and apoptosis of an ATC‑xenograft tumor were studied by comparing the SOV‑treatment with the control group. The results revealed that treatment of the human ATC cell line 8505C with SOV inhibited cell viability, induced G2/M phase cell cycle arrest, stimulated apoptosis and reduced mitochondrial membrane potential in a concentration‑dependent manner. These findings were confirmed in vivo in a nude mouse ATC xenograft model. In conclusion, the present study demonstrated that SOV inhibited human ATC by regulating proliferation, cell cycle progression and apoptosis, thus suggesting that SOV may be considered a novel option for the treatment of ATC.
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May-2019
Volume 17 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Yu Q, Jiang W, Li D, Gu M, Liu K, Dong L, Wang C, Jiang H and Dai W: Sodium orthovanadate inhibits growth and triggers apoptosis of human anaplastic thyroid carcinoma cells in vitro and in vivo. Oncol Lett 17: 4255-4262, 2019
APA
Yu, Q., Jiang, W., Li, D., Gu, M., Liu, K., Dong, L. ... Dai, W. (2019). Sodium orthovanadate inhibits growth and triggers apoptosis of human anaplastic thyroid carcinoma cells in vitro and in vivo. Oncology Letters, 17, 4255-4262. https://doi.org/10.3892/ol.2019.10090
MLA
Yu, Q., Jiang, W., Li, D., Gu, M., Liu, K., Dong, L., Wang, C., Jiang, H., Dai, W."Sodium orthovanadate inhibits growth and triggers apoptosis of human anaplastic thyroid carcinoma cells in vitro and in vivo". Oncology Letters 17.5 (2019): 4255-4262.
Chicago
Yu, Q., Jiang, W., Li, D., Gu, M., Liu, K., Dong, L., Wang, C., Jiang, H., Dai, W."Sodium orthovanadate inhibits growth and triggers apoptosis of human anaplastic thyroid carcinoma cells in vitro and in vivo". Oncology Letters 17, no. 5 (2019): 4255-4262. https://doi.org/10.3892/ol.2019.10090