Ewing's sarcoma of the cervix: A case report of an unusual diagnosis in pregnancy treated with surgery, adjuvant VIDE and radiotherapy

Kyriazoglou,Anastasios; Tsironis,Georgios; Liontos,Michalis; Papakosta,Alexandra; Mahaira,Luisa; Thomakos,Nikolaos; Morphopoulos,Georgios; Papaspyrou,Irene; Bamias,Aristotelis

doi:10.3892/ol.2019.10267

Ewing's sarcoma of the cervix: A case report of an unusual diagnosis in pregnancy treated with surgery, adjuvant VIDE and radiotherapy

Authors:
- Anastasios Kyriazoglou
- Georgios Tsironis
- Michalis Liontos
- Alexandra Papakosta
- Luisa Mahaira
- Nikolaos Thomakos
- Georgios Morphopoulos
- Irene Papaspyrou
- Aristotelis Bamias
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Affiliations: Department of Clinical Therapeutics, Alexandra Hospital, 11528 Athens, Greece, Department of Genetics, Agios Savvas Hospital, Alexandra Hospital, 11528 Athens, Greece, Department of Obstetrics and Gynecology, Alexandra Hospital, 11528 Athens, Greece, Department of Pathology, Alexandra Hospital, 11528 Athens, Greece
Published online on: April 18, 2019 https://doi.org/10.3892/ol.2019.10267
Pages: 5529-5535
Copyright: © Kyriazoglou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Ewing's sarcoma of the cervix is a rare entity and presents with considerable challenges in diagnosis and therapy. Herein, we report a case of a cervical Ewing's sarcoma presenting with FIGO stage Ib, diagnosed during the first trimester of the patient's pregnancy. Imaging with CT scans, MRI of her abdomen and PET‑CT verified the locoregional extension of the tumor. The diagnosis was confirmed by immunohistochemistry and molecular analysis. Fluorescence in situ hybridization and RT‑PCR detected the pathognomonic EWS/FLI fusion gene. Favorable prognostic factors regarding the stage, clinocopathological and molecular characteristics of the tumor are also described. Due to the rarity of the disease, at present, there is no universal consensus on the optimal therapeutic approach. The literature has been reviewed and the therapeutic schemes and available clinical data have been discussed. The patient presented in this case report was treated aggressively with tri‑modality therapy and underwent radical hysterectomy followed by adjuvant chemotherapy with Vincristine‑Ifosfamide‑Doxorubicin‑Etoposide and radiotherapy. The patient remains free of this disease 42 months following the diagnosis of her tumor.

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