Diagnostic value of hepatic artery perfusion fraction combined with TGF-β in patients with hepatocellular carcinoma

Liu,Qingxu; Gao,Yan; Wang,Yongxue; Du,Jiexin; Yin,Qiang; Shi,Kewei

doi:10.3892/ol.2019.10228

Diagnostic value of hepatic artery perfusion fraction combined with TGF-β in patients with hepatocellular carcinoma

Authors:
- Qingxu Liu
- Yan Gao
- Yongxue Wang
- Jiexin Du
- Qiang Yin
- Kewei Shi
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Affiliations: Department of Medical Imaging, Affiliated Hospital of Jining Medical University, Jining, Shandong 272000, P.R. China, Department of Radiology, People's Hospital of Rizhao, Rizhao, Shandong 276800, P.R. China, Department of Medical Records, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China, Department of Neurology, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China, Ward 1, Department of Oncology, People's Hospital of Rizhao, Rizhao, Shandong 276800, P.R. China
Published online on: April 8, 2019 https://doi.org/10.3892/ol.2019.10228
Pages: 5635-5641
Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Diagnostic value of hepatic artery perfusion fraction (HAF) combined with transforming growth factor-β (TGF-β) in the diagnosis of primary liver carcinoma (PLC) was evaluated. The clinical data of 128 PLC patients undergoing radical hepatectomy in Affiliated Hospital of Jining Medical University were regarded as the study group. Seventy‑four healthy volunteers examined in Affiliated Hospital of Jining Medical University were collected as the control group. Double-antibody sandwich enzyme-linked immunosorbent assay was used to detect the expression level of serum TGF-β. The upper abdomen of the subjects was scanned by a 64-slice spiral CT, and the perfusion parameters were analyzed and calculated. According to the HAF and the expression level of TGF-β in the two groups, single and combined detection of TGF-β and HAF parameters were detected, respectively, by ROC curve. The expression of TGF-β in serum of the study group was higher than that of the control group (P<0.05). The expression level of serum TGF-β was closely related to total bilirubin, ascites, TNM stage, prothrombin time and tumor diameter. Blood flow (BF), blood volume (BV), permeability surface (PS), HAF and other perfusion parameters in the study group were higher than those in the control group (P<0.05). The specificity and sensitivity of TGF-β expression level in diagnosing PLC were 73 and 93%, respectively; the specificity and sensitivity of HAF parameter in diagnosing PLC were 73 and 100%, respectively; the specificity and sensitivity of HAF parameter combined with TGF-β expression level were 84 and 100%, respectively. TGF-β is highly expressed in serum of PLC patients; HAF parameter combined with TGF-β expression level can improve the specificity and has an important value in the diagnosis of PLC, which is worthy of clinical promotion.

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