Anesthetic effect of propofol combined with remifentanil or sevoflurane anesthesia on patients undergoing radical gastrectomy

Feng,Yazhen; Li,Ji; Wang,Hushan; Duan,Zongsheng

doi:10.3892/ol.2019.10238

Anesthetic effect of propofol combined with remifentanil or sevoflurane anesthesia on patients undergoing radical gastrectomy

Authors:
- Yazhen Feng
- Ji Li
- Hushan Wang
- Zongsheng Duan
View Affiliations

Affiliations: Department of Anesthesiology, The First Bethune Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Operation Room, The First Bethune Hospital of Jilin University, Changchun, Jilin 130021, P.R. China
Published online on: April 10, 2019 https://doi.org/10.3892/ol.2019.10238
Pages: 5669-5673

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Anesthetic effect of propofol combined with remifentanil or sevoflurane intravenous anesthesia on patients undergoing radical gastrectomy was evaluated. The clinical data of 516 cancer patients who received radical gastrectomy in the First Bethune Hospital of Jilin University between January 2011 and December 2017 were retrospectively analyzed. In total 203 patients with propofol combined with remifentanil anesthesia were used as group A, and 313 patients with propofol combined with sevoflurane anesthesia as group B. The changes of respiration and circulation were analyzed at the time of entering the operating room (t0), the beginning of the operation (t1), 10 min after the beginning of the operation (t2) and 10 min after operation (t3). The onset time of anesthesia, the total time of operation, the time of waking up after operation and the time of leaving the operating room were analyzed. The effects of sedation and amnesia were evaluated, and the occurrence of adverse reactions were recorded. The inhibition of circulation and respiration was more obvious at t1 and t2 in group A when compared to group B (P<0.05), and the respiration and circulation in group B was more stable than that in group A (P<0.001). Patients' sedation scores in group A were lower than those in group B, and the difference was statistically significant (P<0.05); there were 56 (27.59%) patients and 30 (9.58%) patients with postoperative pain in group A and group B, respectively (P<0.001). The application of propofol combined with sevoflurane in the anesthesia of patients undergoing radical gastrectomy can make the respiration and circulation more stable, and reduce the incidence of postoperative pain and adverse reactions.

View Figures

View References

1	Lan L, Zhao F, Cai Y, Wu RX and Meng Q: Epidemiological analysis on mortality of cancer in China, 2015. Zhonghua Liu Xing Bing Xue Za Zhi. 39:32–34. 2018.(In Chinese). PubMed/NCBI
2	He J: Strengthen the cancer surveillance to promote cancer prevention and control in China. Zhonghua Zhong Liu Za Zhi. 40:1–4. 2018.(In Chinese). PubMed/NCBI
3	Hayashi K, Murata K, Naito A, Kagawa Y, Kawai K, Mori R, Nose Y, Akiyama Y, Sakamoto T, Murakami K, et al: A case of resection of obstructive colon cancer associated with aspiration pneumonia, under combined epidural-spinal anesthesia. Gan To Kagaku Ryoho. 44:1970–1972. 2017.(In Japanese). PubMed/NCBI
4	Kim MH, Kim DW, Kim JH, Lee KY, Park S and Yoo YC: Does the type of anesthesia really affect the recurrence-free survival after breast cancer surgery? Oncotarget. 8:90477–90487. 2017.PubMed/NCBI
5	Lee KH, Rim SK, Lee JY, Lee SY, Lee SN, Lee EJ and Lee JH: Effects of pretreatment with intravenous palonosetron for propofol-remifentanil-based anesthesia in breast and thyroid cancer surgery: A double-blind, randomized, controlled study. Korean J Anesthesiol. 67:13–19. 2014. View Article : Google Scholar : PubMed/NCBI
6	Hao Z, Yali H, Xiangjun L, Fusheng D and Ruihua L: Comparison between propofol and propofol-remifentanil sedation under target-controlled infusion for impacted supernumerary teeth extraction surgery for children. Hua Xi Kou Qiang Yi Xue Za Zhi. 35:408–412. 2017.(In Chinese). PubMed/NCBI
7	Peng K, Liu HY, Wu SR, Liu H, Zhang ZC and Ji FH: Does propofol anesthesia lead to less postoperative pain compared with inhalational anesthesia?: A systematic review and meta-analysis. Anesth Analg. 123:846–858. 2016. View Article : Google Scholar : PubMed/NCBI
8	Liu S, Gu X, Zhu L, Wu G, Zhou H, Song Y and Wu C: Effects of propofol and sevoflurane on perioperative immune response in patients undergoing laparoscopic radical hysterectomy for cervical cancer. Medicine (Baltimore). 95:e54792016. View Article : Google Scholar : PubMed/NCBI
9	Chen Y, Liang M, Zhu Y and Zhou D: The effect of propofol and sevoflurane on the perioperative immunity in patients under laparoscopic radical resection of colorectal cancer. Zhonghua Yi Xue Za Zhi. 95:3440–3444. 2015.(In Chinese). PubMed/NCBI
10	Hassan WM, Nasir YM, Zaini RH and Shukeri WF: Target-controlled infusion propofol versus sevoflurane anaesthesia for emergency traumatic brain surgery: Comparison of the outcomes. Malays J Med Sci. 24:73–82. 2017.PubMed/NCBI
11	Zhang GH and Wang W: Effects of sevoflurane and propofol on the development of pneumonia after esophagectomy: A retrospective cohort study. BMC Anesthesiol. 17:1642017. View Article : Google Scholar : PubMed/NCBI
12	Wang C, Ni C, Li G, Li Y, Tao L, Li N, Wang J and Guo X: Effects of sevoflurane versus propofol on cerebrovascular reactivity to carbon dioxide during laparoscopic surgery. Ther Clin Risk Manag. 13:1349–1355. 2017. View Article : Google Scholar : PubMed/NCBI
13	Kratzer S, Mattusch C, Garcia PS, Schmid S, Kochs E, Rammes G, Schneider G, Kreuzer M and Haseneder R: Propofol and sevoflurane differentially modulate cortical depolarization following electric stimulation of the ventrobasal thalamus. Front Comput Neurosci. 11:1092017. View Article : Google Scholar : PubMed/NCBI
14	Recart A, Gasanova I, White PF, Thomas T, Ogunnaike B, Hamza M and Wang A: The effect of cerebral monitoring on recovery after general anesthesia: A comparison of the auditory evoked potential and bispectral index devices with standard clinical practice. Anesth Analg. 97:1667–1674. 2003. View Article : Google Scholar : PubMed/NCBI
15	Kong J, Wu SD and Su Y: Translumenal single-incision laparoscopy radical gastrectomy with D2 lymph node dissection for early gastric cancer - primary experience with less invasive surgery in China. J Laparoendosc Adv Surg Tech A. 23:141–145. 2013. View Article : Google Scholar : PubMed/NCBI
16	Andra E and Julie K: Bispectral index monitoring during sedation with sevoflurane, mmifazolam, and propofol. Anesthesiology. 95:112006.
17	Moradkhani MR and Karimi A: Role of drug anesthesia and cancer. Drug Res (Stuttg). 68:125–131. 2018. View Article : Google Scholar : PubMed/NCBI
18	Cho JS, Lee MH, Kim SI, Park S, Park HS, Oh E, Lee JH and Koo BN: The effects of perioperative anesthesia and analgesia on immune function in patients undergoing breast cancer resection: A prospective randomized study. Int J Med Sci. 14:970–976. 2017. View Article : Google Scholar : PubMed/NCBI
19	Sekandarzad MW, van Zundert AA, Doornebal CW and Hollmann MW: Regional anesthesia and analgesia in cancer care: Is it time to break the bad news? Curr Opin Anaesthesiol. 30:606–612. 2017. View Article : Google Scholar : PubMed/NCBI
20	Barela CA: The effect of anesthesia on cancer metastasis. Gastroenterol Nurs. 40:75–76. 2017. View Article : Google Scholar : PubMed/NCBI
21	Han Y, Han L, Dong M, Sun Q, Ding K, Zhang Z, Cao J and Zhang Y: Comparison of a loading dose of dexmedetomidine combined with propofol or sevoflurane for hemodynamic changes during anesthesia maintenance: A prospective, randomized, double-blind, controlled clinical trial. BMC Anesthesiol. 18:122018. View Article : Google Scholar : PubMed/NCBI
22	Zhang L, Chen C, Wang L, Cheng G, Wu WW and Li YH: Awakening from anesthesia using propofol or sevoflurane with epidural block in radical surgery for senile gastric cancer. Int J Clin Exp Med. 8:19412–19417. 2015.PubMed/NCBI
23	Annigeri RV and Patil RS: A retrospective analysis on anesthetic management during rigid bronchoscopy in children with foreign body aspiration: Propofol and sevoflurane with controlled ventilation. Anesth Essays Res. 11:871–874. 2017. View Article : Google Scholar : PubMed/NCBI
24	Tian HT, Duan XH, Yang YF, Wang Y, Bai QL and Zhang X: Effects of propofol or sevoflurane anesthesia on the perioperative inflammatory response, pulmonary function and cognitive function in patients receiving lung cancer resection. Eur Rev Med Pharmacol Sci. 21:5515–5522. 2017.PubMed/NCBI
25	De Oliveira GS Jr, Bialek J, Rodes ME, Kendall MC and McCarthy RJ: The effect of sevoflurane compared to propofol maintenance on post-surgical quality of recovery in patients undergoing an ambulatory gynecological surgery: A prospective, randomized, double-blinded, controlled, clinical trial. J Clin Anesth. 43:70–74. 2017. View Article : Google Scholar : PubMed/NCBI
26	Tang L, Liu H, Wu Y, Li M, Li W, Jiang M, Hou J, Jiang Y, Xia Z and Meng Q: Sevoflurane may be more beneficial than propofol in patients receiving endoscopic variceal ligation and endoscopic variceal sclerotherapy: A randomized, double-blind study. Exp Ther Med. 14:3145–3152. 2017. View Article : Google Scholar : PubMed/NCBI
27	Robba C, Qeva E, Borsellino B, Aloisio S, Tosti G and Bilotta F: Effects of propofol or sevoflurane anesthesia induction on hemodynamics in patients undergoing fiberoptic intubation for cervical spine surgery: A randomized, controlled, clinical trial. J Anaesthesiol Clin Pharmacol. 33:215–220. 2017.PubMed/NCBI