Open Access

DNA topoisomerase IIα and RAD21 cohesin complex component are predicted as potential therapeutic targets in bladder cancer

  • Authors:
    • Zhiling Yu
    • Qiuping Xu
    • Guixue Wang
    • Molly Rowe
    • Cameron Driskell
    • Qian Xie
    • Minhong Wu
    • Dongyu Jia
  • View Affiliations

  • Published online on: May 17, 2019     https://doi.org/10.3892/ol.2019.10365
  • Pages: 518-528
  • Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cancer is essentially a genetic disease. Accumulated gene mutations accelerate genome instability, which eventually leads to uncontrollable growth of the tumor. Bladder cancer is the most common form of urinary tract cancer. This form of cancer has a poor prognosis due to its clinical heterogeneity and molecular diversity. Despite recent scientific advances, the knowledge and treatment of bladder cancer still lags behind that of other types of solid tumor. In the present study, available large data portals and other studies were used to obtain clinically relevant information, and the data were systematically processed to decipher the genes associated with bladder cancer. Genes associated with the survival time of patients with bladder cancer were successfully identified. The genes were enriched in common biological processes and pathways, and upregulated in tumor samples from patients. Among the top genes identified as associated with good or poor survival in bladder cancer, DNA topoisomerase IIα (TOP2α) and RAD21 cohesin complex component (RAD21) were also increased in bladder cancer tissues and cell lines. Therefore, TOP2α and RAD21 could be used as potential therapeutic targets in bladder cancer.
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July-2019
Volume 18 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Yu Z, Xu Q, Wang G, Rowe M, Driskell C, Xie Q, Wu M and Jia D: DNA topoisomerase IIα and RAD21 cohesin complex component are predicted as potential therapeutic targets in bladder cancer. Oncol Lett 18: 518-528, 2019
APA
Yu, Z., Xu, Q., Wang, G., Rowe, M., Driskell, C., Xie, Q. ... Jia, D. (2019). DNA topoisomerase IIα and RAD21 cohesin complex component are predicted as potential therapeutic targets in bladder cancer. Oncology Letters, 18, 518-528. https://doi.org/10.3892/ol.2019.10365
MLA
Yu, Z., Xu, Q., Wang, G., Rowe, M., Driskell, C., Xie, Q., Wu, M., Jia, D."DNA topoisomerase IIα and RAD21 cohesin complex component are predicted as potential therapeutic targets in bladder cancer". Oncology Letters 18.1 (2019): 518-528.
Chicago
Yu, Z., Xu, Q., Wang, G., Rowe, M., Driskell, C., Xie, Q., Wu, M., Jia, D."DNA topoisomerase IIα and RAD21 cohesin complex component are predicted as potential therapeutic targets in bladder cancer". Oncology Letters 18, no. 1 (2019): 518-528. https://doi.org/10.3892/ol.2019.10365